Comparing Venlafaxine vs Zoloft

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Venlafaxine Remove Venlafaxine from your drug comparison	Zoloft Remove Zoloft from your drug comparison	Add another drug to compare

Venlafaxine

Zoloft sertraline

Venlafaxine is an antidepressant that may also be used for mood disorders and off-label for some other conditions such as hot flashes. It may cause a discontinuation syndrome if abruptly stopped... View more

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Obsessive Compulsive Disorder, Major Depressive Disorder, Panic Disorder... View more

Prescription only

Ratings & Reviews

View all 2325 reviews

View all 1547 reviews

Drug Class

Serotonin-norepinephrine reuptake inhibitors

Selective serotonin reuptake inhibitors

Side Effects

Commonly reported side effects include: anorgasmia, asthenia, constipation, dizziness, drowsiness, insomnia, nausea, nervousness, headache, anorexia, decreased appetite, delayed ejaculation, diaphoresis, and xerostomia.

See the full venlafaxine side effects document.

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

See the full Zoloft side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 each
Dosage	150 mg
Per Unit^*	$0.68
Cost^*	$34.06

View all venlafaxine prices

Quantity	30 tablet
Dosage	100 mg
Per Unit^*	$13.13
Cost^*	$393.84

View all Zoloft prices and generic prices

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral capsule, extended release
Oral tablet
Oral tablet, extended release

Oral concentrate
Oral tablet

Brand Names

Effexor, Effexor XR

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4 hours

66 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 640 drugs are known to interact with venlafaxine:

139 major drug interactions (554 brand and generic names)
496 moderate drug interactions (2167 brand and generic names)
5 minor drug interactions (22 brand and generic names)

A total of 619 drugs are known to interact with Zoloft:

141 major drug interactions (560 brand and generic names)
471 moderate drug interactions (1937 brand and generic names)
7 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of venlafaxine such as dizziness, drowsiness... View more

You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Disease Interactions

First Approval Date

December 28, 1993

December 30, 1991

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer