Comparing Venlafaxine vs Zoloft
| Venlafaxine | Zoloft |
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| Venlafaxine | Zoloft (sertraline) |
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Prescription only
Venlafaxine is an antidepressant that may also be used for mood disorders and off-label for some other conditions such as hot flashes. It may cause a discontinuation syndrome if abruptly stopped... View more |
Prescription only
Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Obsessive Compulsive Disorder, Major Depressive Disorder, Panic Disorder... View more |
Related suggestions Depression
Major Depressive Disorder
Panic Disorder
Obsessive Compulsive Disorder
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| More about Venlafaxine | More about Zoloft (sertraline) | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Venlafaxine has an average rating of 6.4 out of 10 from a total of 2636 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 28% reported a negative effect. |
Zoloft has an average rating of 7.2 out of 10 from a total of 1851 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Commonly reported side effects include:
See also: venlafaxine side effects in more detail. |
Common side effects include:
See also: Zoloft side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all venlafaxine prices |
View all Zoloft prices and generic prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Effexor, Effexor XR |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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4 hours |
66 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 662 drugs are known to interact with venlafaxine:
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A total of 642 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 28, 1993 |
December 30, 1991 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.