Tolbutamide Alternatives Compared
| Tolbutamide | Ozempic | Rybelsus |
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| Tolbutamide | Ozempic (semaglutide) | Rybelsus (semaglutide) |
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Prescription only
Prescribed for Diabetes - Type 2. tolbutamide may also be used for purposes not listed in this medication guide. |
Prescription only
Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Related suggestions Diabetes, Type 2
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| More about Tolbutamide | More about Ozempic (semaglutide) | More about Rybelsus (semaglutide) | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Be the first to share your experience with this drug. |
Ozempic has an average rating of 6.5 out of 10 from a total of 1325 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 25% reported a negative effect. |
Rybelsus has an average rating of 6.3 out of 10 from a total of 252 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 26% reported a negative effect. |
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| Drug Class | ||||||||||||||||||
| Side Effects | ||||||||||||||||||
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See also: tolbutamide side effects in more detail. |
See also: Ozempic side effects in more detail. |
See also: Rybelsus side effects in more detail. |
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| Generic Availability | ||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Ozempic prices |
View all Rybelsus prices |
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| Dosage Forms Available | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
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N/A |
Other semaglutide brands include: Rybelsus, Wegovy | Other semaglutide brands include: Ozempic, Wegovy | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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25 hours |
168 hours |
168 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 509 drugs are known to interact with tolbutamide:
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A total of 264 drugs are known to interact with Ozempic:
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A total of 264 drugs are known to interact with Rybelsus:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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May 31, 1957 |
N/A |
September 20, 2019 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.