Comparing St. John's Wort vs Trintellix
| St. john's wort | Trintellix (vortioxetine) |
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| St. john's wort | Trintellix (vortioxetine) |
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Over-the-counter
Used for Depression, Night Terrors. St. john's wort may also be used for purposes not listed in this medication guide. |
Prescription only
Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more |
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| More about St. john's wort | More about Trintellix (vortioxetine) | ||||||||
| Ratings & Reviews | |||||||||
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St. john's wort has an average rating of 7.8 out of 10 from a total of 144 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 15% reported a negative effect. |
Trintellix has an average rating of 6.0 out of 10 from a total of 1130 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 32% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all St. john's wort side effects |
View all Trintellix side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Trintellix prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
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N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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N/A |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category N
Not classified
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 634 drugs are known to interact with St. john's wort:
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A total of 355 drugs are known to interact with Trintellix:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||
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N/A |
September 30, 2013 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.