Comparing Skyla vs Xulane

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Skyla levonorgestrel

Xulane ethinyl estradiol / norelgestromin

Prescribed for Birth Control. Skyla may also be used for purposes not listed in this medication guide.

Prescribed for Birth Control. Xulane may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 1507 reviews

View all 443 reviews

Drug Class

Contraceptives

Side Effects

Common side effects include: amenorrhea.

See the full Skyla side effects document.

See the full Xulane side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	1 device
Dosage	13.5 mg
Per Unit^*	$878.18
Cost^*	$878.18

View all Skyla prices and generic prices

Quantity	3 film, extended release
Dosage	35 mcg-150 mcg/24 hr
Per Unit^*	$19.45
Cost^*	$58.36

View all Xulane prices

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Generic Availability

Yes

Dosage Form(s) Available

Intrauterine device

Transdermal film, extended release

Brand Names

Other levonorgestrel brands include: Aftera, AfterPill, AfterPlan, Athentia Next, BionaFem, EContra EZ, EContra One-Step, Fallback Solo, Kyleena, Liletta, Mirena, Morning After, My Choice, My Way, New Day, Next Choice One Dose, Opcicon One-Step, Option 2, Plan B One-Step, PostDay One-Step, Preventeza, React, Take Action View more Other ethinyl estradiol / norelgestromin brands include: Onsura, Zafemy

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

45 hours

32 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Drug Interactions

A total of 216 drugs are known to interact with Skyla:

32 major drug interactions (89 brand and generic names)
172 moderate drug interactions (546 brand and generic names)
12 minor drug interactions (33 brand and generic names)

A total of 419 drugs are known to interact with Xulane:

36 major drug interactions (99 brand and generic names)
338 moderate drug interactions (1210 brand and generic names)
45 minor drug interactions (481 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

N/A

April 16, 2014

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer