Skyla Interactions
There are 261 drugs known to interact with Skyla (levonorgestrel), along with 12 disease interactions, and 5 alcohol/food interactions. Of the total drug interactions, 60 are major, 187 are moderate, and 14 are minor.
- View all 261 medications that may interact with Skyla
- View Skyla alcohol/food interactions (5)
- View Skyla disease interactions (12)
Most frequently checked interactions
View interaction reports for Skyla (levonorgestrel) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- amitriptyline
- amitriptyline
- bupropion
- bupropion
- fluoxetine
- fluoxetine
- gabapentin
- gabapentin
- hydroxyzine
- hydroxyzine
- ibuprofen
- ibuprofen
- lamotrigine
- lamotrigine
- omeprazole
- omeprazole
- Prozac (fluoxetine)
- Prozac (fluoxetine)
- trazodone
- trazodone
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Zofran (ondansetron)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Skyla alcohol/food interactions
There are 5 alcohol/food interactions with Skyla (levonorgestrel).
Skyla disease interactions
There are 12 disease interactions with Skyla (levonorgestrel) which include:
- abnormal genital bleeding
- hepatic neoplasms
- breast malignancy
- liver disease
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
- cardiovascular disease
- hyperlipidemia
- weight gain
Report options
More about Skyla (levonorgestrel)
- Skyla consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (1,537)
- Latest FDA alerts (1)
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: contraceptives
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.