Skyla Drug Interactions
Currently displaying a list of 261 drugs known to interact with Skyla (levonorgestrel).
- 60 major drug interactions
- 187 moderate drug interactions
- 14 minor drug interactions
Medications known to interact with Skyla
Note: Showing generic names only.
- abametapir topical
- abrocitinib
- acarbose
- acetohexamide
- acitretin
- adagrasib
- adalimumab
- albiglutide
- alefacept
- alogliptin
- aminoglutethimide
- aminophylline
- amobarbital
- amprenavir
- anakinra
- apalutamide
- aprepitant
- armodafinil
- asciminib
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atorvastatin
- avacopan
- baricitinib
- belzutifan
- berotralstat
- bexagliflozin
- bexarotene
- bimekizumab
- boceprevir
- bosentan
- brigatinib
- brivaracetam
- brodalumab
- butabarbital
- butalbital
- calaspargase pegol
- canagliflozin
- canakinumab
- carbamazepine
- carfilzomib
- cenobamate
- chloramphenicol
- chlorpropamide
- cholestyramine
- cladribine
- clarithromycin
- clobazam
- clotrimazole
- clozapine
- cobicistat
- colesevelam
- colestipol
- conivaptan
- cyclosporine
- dabrafenib
- dapagliflozin
- daridorexant
- darunavir
- dasatinib
- deferasirox
- delavirdine
- dexamethasone
- diltiazem
- divalproex sodium
- dronedarone
- dulaglutide
- duvelisib
- echinacea
- efavirenz
- elafibranor
- elagolix
- emapalumab
- empagliflozin
- enasidenib
- encorafenib
- entrectinib
- enzalutamide
- ertugliflozin
- erythromycin
- eslicarbazepine
- ethanol
- etravirine
- etretinate
- exenatide
- fedratinib
- felbamate
- fenfluramine
- flibanserin
- fluconazole
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- frovatriptan
- indinavir
- infliximab
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iptacopan
- isavuconazonium
- isotretinoin
- itraconazole
- ivacaftor
- ivosidenib
- lamotrigine
- lapatinib
- larotrectinib
- lefamulin
- lenacapavir
- lesinurad
- levoketoconazole
- linaclotide
- linagliptin
- liraglutide
- lixisenatide
- lomitapide
- lonafarnib
- lonapegsomatropin
- lorlatinib
- mavacamten
- mephobarbital
- metformin
- metreleptin
- miconazole
- mifepristone
- miglitol
- miltefosine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- momelotinib
- morphine
- morphine liposomal
- mycophenolate mofetil
- mycophenolic acid
- pacritinib
- pegaspargase
- pentobarbital
- perampanel
- pexidartinib
- phenobarbital
- phenylbutazone
- phenytoin
- pioglitazone
- pirtobrutinib
- pitolisant
- posaconazole
- pralsetinib
- pramlintide
- primidone
- prucalopride
- repaglinide
- repotrectinib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- ritlecitinib
- ritonavir
- rosiglitazone
- rosuvastatin
- rufinamide
- ruxolitinib
- ruxolitinib topical
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- secobarbital
- secukinumab
- selegiline
- selpercatinib
- selumetinib
- semaglutide
- siltuximab
- sirolimus
- sitagliptin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotorasib
- st. john's wort
- stiripentol
- sugammadex
- sulfinpyrazone
- tacrolimus
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- temsirolimus
- teriflunomide
- theophylline
- ticagrelor
- tirzepatide
- tivozanib
- tizanidine
- tocilizumab
- tofacitinib
- tolazamide
- tolbutamide
- topiramate
- tovorafenib
- tranexamic acid
- trofinetide
- troglitazone
- troleandomycin
Skyla alcohol/food interactions
There are 5 alcohol/food interactions with Skyla (levonorgestrel).
Skyla disease interactions
There are 12 disease interactions with Skyla (levonorgestrel) which include:
- abnormal genital bleeding
- hepatic neoplasms
- breast malignancy
- liver disease
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
- cardiovascular disease
- hyperlipidemia
- weight gain
Report options
More about Skyla (levonorgestrel)
- Skyla consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1,537)
- Latest FDA alerts (1)
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: contraceptives
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.