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Ethinyl estradiol / norelgestromin Pregnancy and Breastfeeding Warnings

Ethinyl estradiol / norelgestromin is also known as: Ortho Evra, Xulane

Ethinyl estradiol / norelgestromin Pregnancy Warnings

Ethinyl estradiol-norelgestromin transdermal patch has been assigned to pregnancy category X by the FDA. There is no indication for the use of hormonal contraceptive combinations during pregnancy. Although some reports have suggested that oral contraceptive hormones may cause a variety of congenital malformations, recent studies (including a meta-analysis of prospective studies) have suggested that an association between oral contraceptive use and congenital malformations does not exist. Some progestins may cause masculinization of female infants.

See references

Ethinyl estradiol / norelgestromin Breastfeeding Warnings

There are no data on the excretion of ethinyl estradiol and norelgestromin (transdermal patch) into human milk. Contraceptive steroids given in the postpartum period may interfere with the quality and quantity of breast milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Ortho Evra (ethinyl estradiol-norelgestromin)." Janssen Pharmaceuticals, Titusville, NJ.

References for breastfeeding information

  1. Audet MC, Moreau M, Kiltun WD, et. "Evaluation of contraceptive efficacy and cycle control of a transdermal contraceptive patch vs an oral contraceptive: a randomized controlled trial." JAMA 285 (2001): 2347-54
  2. "Product Information. Ortho Evra (ethinyl estradiol-norelgestromin)." Janssen Pharmaceuticals, Titusville, NJ.

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