Comparing Prozac vs Wellbutrin XL

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Prozac fluoxetine

Wellbutrin XL bupropion

Prozac may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 1070 reviews

View all 386 reviews

Drug Class

Selective serotonin reuptake inhibitors

Miscellaneous antidepressants

Side Effects

See the full Prozac side effects document.

Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, and xerostomia.

See the full Wellbutrin XL side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 capsule
Dosage	20 mg
Per Unit^*	$17.85
Cost^*	$535.36

View all Prozac prices and generic prices

Quantity	30 tablet, extended release
Dosage	150 mg/24 hours
Per Unit^*	$55.51
Cost^*	$1,665.16

View all Wellbutrin XL prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral capsule

Oral tablet, extended release

Brand Names

N/A

Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

210 hours

30 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 637 drugs are known to interact with Prozac:

148 major drug interactions (567 brand and generic names)
467 moderate drug interactions (1964 brand and generic names)
22 minor drug interactions (94 brand and generic names)

A total of 423 drugs are known to interact with Wellbutrin XL:

212 major drug interactions (924 brand and generic names)
206 moderate drug interactions (862 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

December 29, 1987

August 28, 2003

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Prescribing Information

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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