Comparing Prozac vs Wellbutrin XL
| Prozac | Wellbutrin XL |
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| Prozac (fluoxetine) | Wellbutrin XL (bupropion) |
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Prescription only
Prozac may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more |
Prescription only
Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Related suggestions Depression
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| More about Prozac (fluoxetine) | More about Wellbutrin XL (bupropion) | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Prozac has an average rating of 7.2 out of 10 from a total of 1162 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 20% reported a negative effect. |
Wellbutrin XL has an average rating of 7.4 out of 10 from a total of 466 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Side Effects | |||||||||||||||||
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See also: Prozac side effects in more detail. |
Common side effects include:
See also: Wellbutrin XL side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prozac prices and generic prices |
View all Wellbutrin XL prices and generic prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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210 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 654 drugs are known to interact with Prozac:
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A total of 484 drugs are known to interact with Wellbutrin XL:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 29, 1987 |
August 28, 2003 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.