Comparing Provigil vs Xyrem
| Provigil | Xyrem |
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| Provigil (modafinil) | Xyrem (sodium oxybate) |
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Prescription only
Prescribed for Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Shift Work Sleep Disorder. Provigil may also be used for purposes not listed in this medication guide. |
Prescription only
Xyrem is a Schedule III controlled substance when prescribed to treat narcolepsy; however, there is a high risk of abuse associated with it and people who misuse it or sell it to other people are... View more |
Related suggestions |
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| More about Provigil (modafinil) | More about Xyrem (sodium oxybate) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Provigil has an average rating of 7.5 out of 10 from a total of 167 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect. |
Xyrem has an average rating of 7.7 out of 10 from a total of 107 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 14% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: Provigil side effects in more detail. |
See also: Xyrem side effects in more detail. |
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| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Provigil prices |
View all Xyrem prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Other sodium oxybate brands include: Lumryz | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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15 hours |
1 hour |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 507 drugs are known to interact with Provigil:
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A total of 343 drugs are known to interact with Xyrem:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 24, 1998 |
July 17, 2002 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.