Comparing Primidone vs Zonegran

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Primidone	Zonegran (zonisamide)	Enter another drug to compare

Primidone

Zonegran (zonisamide)

Prescription only

Prescribed for Benign Essential Tremor, Epilepsy, Seizures. Primidone may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Seizures. Zonegran may also be used for purposes not listed in this medication guide.

More about Primidone

More about Zonegran (zonisamide)

Ratings & Reviews

Primidone has an average rating of 6.0 out of 10 from a total of 109 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 28% reported a negative effect.

Zonegran has an average rating of 6.5 out of 10 from a total of 66 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 109 reviews

View all 66 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (14.7%)
Tremors (11.0%)
Drowsiness (7.3%)
Nausea (7.3%)
Tiredness (7.3%)
Disorientation (4.6%)
Brain fog (3.7%)

View all Primidone side effects

Memory loss (13.6%)
Depression (10.6%)
Headaches (10.6%)
Loss of appetite (10.6%)
Weight loss (10.6%)
Irritability (7.6%)
Anger (6.1%)

View all Zonegran side effects

Drug Class

Barbiturate anticonvulsants

Carbonic anhydrase inhibitor anticonvulsants

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.25
Cost^*	$24.57

View all Primidone prices

Quantity	100 capsule
Strength	25 mg
Per unit^*	$19.41
Cost^*	$1,940.90

View all Zonegran prices

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Dosage Forms

Oral tablet

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12 hours

63 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 686 drugs are known to interact with Primidone:

237 major drug interactions (701 brand and generic names)
420 moderate drug interactions (2766 brand and generic names)
29 minor drug interactions (105 brand and generic names)

A total of 413 drugs are known to interact with Zonegran:

101 major drug interactions (588 brand and generic names)
307 moderate drug interactions (1119 brand and generic names)
5 minor drug interactions (11 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using primidone together with alcohol, this can add to dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of zonisamide such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

March 08, 1954

March 27, 2000

WADA Class View classifications

N/A

More Information

Patient Resources

Zonegran uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Primidone vs Zonegran

See also:

Lamictal

Carbamazepine

Botox

Levetiracetam

Lyrica

Topiramate

Diazepam

Lorazepam

Pregabalin

Lamotrigine

Further information

Comparing Primidone vs Zonegran

See also:

Further information

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