Comparing Prazosin vs Zoloft

For Post Traumatic Stress Disorder I am 63 and have had CPTSD all my life. Prazosin has helped a lot. BUT it's been rocky. The first dose I took felt like a miracle. I was serene and amazed. But then my nervous system got confused. Used to the constant fight stimulus. I would get wired taking it before sleep. Took it during the day which helped. WHAT I experienced felt like when one's arm goes numb and then circulation returns. My whole body felt like it was coming alive again. It hurt but I knew it was good. My digestion worked better. (makes sense) I had insomnia about 3 nights a week. After 2 months I'm so so much better - hardly any hypervigilance, less nightmares. So decrease the dose if you need to and gradually build it up if you have the problems I had.

For Post Traumatic Stress Disorder I'm a former paramedic with Complex-PTSD, and I've been taking Prazosin for one year to help with my nightmares. I used to kick and scream during my nightmares. I woke up so sweaty I had to change during the night, and sleep in a different spot. I still have nightmares, but they aren't terrifying like they used to be. I no longer have night sweats. My only beef is with the major dizziness and tachycardia the following morning. I've tried stopping these meds because of the side-effects, but trust me: the benefits far outweigh them.

For Depression Just take these reviews with a grain of salt. A lot of reviews after taking one day, couple weeks etc. you need a full three months for maximum effectiveness. Not that it takes that long to start getting relief. Side effects are common while your body adjusts. Some of them will go away. I had no troublesome side effects with Zoloft. I always have to start out gradually. Maybe even more than they say bc I’m sensitive to meds. I got big relief from depression. Panic attacks went away. OCD went away. The cons are it made me not very motivated, felt kind of numb to strong feelings. Not feeling urgency about my life. I wouldn’t take it again for years bc it blocked my clear perspective. But it was great to get me stabilized. Things that really help but can’t completely replace anti dep is fish oil, vit d, exercise, sunlight, folate like spinach , lentils really good. Also diet really helps. Get a book called the good mood diet. Best wishes

For Depression I'm a 31 year old Male who has had challenges with depression and anxiety throughout my life. I have been on several different meds in my past, including lexapro, paxil, effexor, wellbutrin, prozac, zoloft, and some others as well. Of all of these meds, I've found zoloft works the best for me. However the worst thing I experience with zoloft is decreased libido, as with all of the other meds I've tried, except for wellbutrin. This side effect truly sucks. Zoloft also kind of makes me feel robotic and emotionally numb. Currently I'm experimenting with another medication (viibryd) in attempt to find a med that works without having sexual side effects. However zoloft is my fallback option, because this med at least stabilizes me and helps function in society. Therefore I give this med a 7 out of 10. My advice to everyone is to keep being patient with meds and realize that it might take some time and trial and error. And always keep hanging in there no matter what. Good luck.