Prazosin use while Breastfeeding
Drugs containing Prazosin: Minipress, Minizide
Prazosin Levels and Effects while Breastfeeding
Summary of Use during Lactation
Because little is available on the use of prazosin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Maternal Levels. The manufacturer reports that one mother was studied and excreted at most 3% of the dose into her breastmilk. No study details were presented.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information in nursing mothers was not found as of the revision date. Prazosin does not affect serum prolactin concentration in patients with hypertension. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
1. Schaefer C, Peters P, Miller RK, eds. Drugs during pregnancy and lactation. Treatment options and risk assessment, 2nd ed. Amsterdam; Boston: Elsevier Academic Press. 2007:685.
2. Barbieri C, Caldara R, Ferrari C et al. Metabolic effects of prazosin. Clin Pharmacol Ther. 1980;27:313-6. PMID: 6102000
3. Barbieri C, Ferrari C, Borzio M et al. Metabolic effects of chronic prazosin treatment. Horm Metab Res. 1980;12:331-4. PMID: 6105121
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LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.