Prazosin Dosage
Medically reviewed by Drugs.com. Last updated on Jun 12, 2024.
Applies to the following strengths: 1 mg; 2 mg; 5 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 mg orally 2 or 3 times a day
Maintenance dose: 1 to 20 mg orally per day in divided doses
Comments:
- Titrate slowly as determined by blood pressure response.
- Therapeutic dosages usually range from 6 to 15 mg per day in divided doses.
- Total daily doses greater than 20 mg usually do not increase efficacy, but some patients may benefit from daily doses up to 40 mg per day in divided doses.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Adding a diuretic or another antihypertensive agent:
- Reduce the dose of this drug to 1 or 2 mg three times a day and then retitrate.
Coadministration with phosphodiesterase-5 (PDE-5) inhibitors:
- Initiate the PDE-5 inhibitor at the lowest dose.
Precautions
Safety and efficacy have not been established in children.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Storage requirements: Protect from light.
Monitoring:
- Cardiovascular: Blood pressure (following the initial dose and dose adjustments)
Patient advice:
- Advise patients how to avoid symptoms associated with lowering of blood pressure (e.g., dizziness, lightheadedness) and what to do if they occur. Also, encourage patients to avoid situations where injury could result if these symptoms occur.
- Inform male patients about the seriousness of priapism and instruct them to seek immediate medical attention if it occurs.
- Advise patients to report current or previous use of this drug to their ophthalmologist.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.