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Silodosin

Generic Name: silodosin (SIL oh DOE sin)
Brand Name: Rapaflo

Medically reviewed by Drugs.com on Dec 17, 2018 – Written by Cerner Multum

What is silodosin?

Silodosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker that is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Silodosin may also be used for purposes not listed in this medication guide.

Important Information

You should not take silodosin if you have severe kidney or liver disease.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You should not take silodosin if you are allergic to it, or if you have:

  • severe liver disease; or

  • severe kidney disease.

Some medicines can cause unwanted or dangerous effects when used with silodosin. Your doctor may change your treatment plan if you also use:

Tell your doctor if you have ever had:

  • low blood pressure;

  • kidney disease (or if you are on dialysis);

  • heart disease;

  • prostate cancer;

  • a condition for which you take a diuretic or "water pill"; or

  • if you are on a low-salt diet.

Silodosin can affect your pupils. If you have cataract surgery, tell your surgeon ahead of time that you use silodosin.

Silodosin is not for use in women, and the effects of this medicine during pregnancy or in breastfeeding women are unknown.

Silodosin is not approved for use by anyone younger than 18 years old.

How should I take silodosin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Silodosin is usually taken once daily with a meal. Follow your doctor's dosing instructions very carefully.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing, then drink a full glass of water.

Silodosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Your blood pressure and prostate will need to be checked often.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking silodosin?

Avoid driving or hazardous activity until you know how silodosin will affect you. Your reactions could be impaired.

Silodosin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe dizziness, or if you feel like you might pass out.

  • severe dizziness, or if you feel like you might pass out.

Common side effects may include:

  • dizziness;

  • headache;

  • diarrhea;

  • abnormal ejaculation; or

  • stuffy nose, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Silodosin dosing information

Usual Adult Dose for Benign Prostatic Hyperplasia:

8 mg orally once a day with a meal

Comments: Patients who have difficulty swallowing may open the capsule and sprinkle the powder on a tablespoonful of applesauce. The applesauce should not be hot, and should be soft enough to be swallowed within 5 minutes without chewing and followed with 8 ounces of cool water.

What other drugs will affect silodosin?

Many drugs can affect silodosin, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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