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Silodosin Dosage

Medically reviewed on December 14, 2017.

Applies to the following strengths: 4 mg; 8 mg

Usual Adult Dose for Benign Prostatic Hyperplasia

8 mg orally once a day with a meal

Comments: Patients who have difficulty swallowing may open the capsule and sprinkle the powder on a tablespoonful of applesauce. The applesauce should not be hot, and should be soft enough to be swallowed within 5 minutes without chewing and followed with 8 ounces of cool water.

Renal Dose Adjustments

Mild renal dysfunction (CrCl 50 to 80 mL/min): No adjustment recommended
Moderate renal dysfunction (CrCl 30 to 50 mL/min): 4 mg orally once a day with a meal
Severe renal dysfunction (CrCl less than 30 mL/min): Contraindicated

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended
Severe liver dysfunction (Child-Pugh 10 or greater): Contraindicated

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:
-Inform patients regarding postural hypotension and related symptoms such as dizziness. Caution patients about driving, operating machinery, or performing hazardous tasks when initiating therapy.
-Inform patients that the most common adverse reaction, orgasm with reduced or no semen, does not pose a safety concern and is reversible upon discontinuation of this drug.
-Advise patients planning cataract surgery or other eye procedures to inform their ophthalmologist regarding use of this drug, even if they are no longer taking it.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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