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Silodosin Side Effects

Medically reviewed by Last updated on Feb 28, 2022.


Commonly reported side effects of silodosin include: retrograde ejaculation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to silodosin: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, silodosin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking silodosin:

Less common

  • Chills
  • cold sweats
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Incidence not known

  • Clay-colored stools
  • dark urine
  • fever
  • headache
  • hives, itching, rash
  • loss of appetite
  • nausea
  • pinpoint red or purple spots on the skin
  • skin blisters
  • stomach pain
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of silodosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change or problem with discharge of semen

Less common

For Healthcare Professionals

Applies to silodosin: oral capsule


The most common adverse reaction was retrograde ejaculation.[Ref]


Very common (10% or more): Retrograde ejaculation (28.1%)

Common (1% to 10%): Prostate-specific antigen (PSA) increased

Uncommon (0.1% to 1%): Priapism[Ref]


Common (1% to 10%): Nasopharyngitis, nasal congestion, sinusitis, rhinorrhea

Postmarketing reports: Pharyngeal edema[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Syncope[Ref]


Common (1% to 10%): Diarrhea, abdominal pain

Postmarketing reports: Swollen tongue[Ref]


Common (1% to 10%): Orthostatic hypotension[Ref]


Common (1% to 10%): Asthenia[Ref]


Common (1% to 10%): Insomnia[Ref]


Frequency not reported: Intraoperative floppy iris syndrome[Ref]


Postmarketing reports: Toxic skin eruption, purpura, skin rash, pruritus, urticaria[Ref]


Postmarketing reports: Jaundice, hepatic function impaired, transaminases increased[Ref]


Postmarketing reports: Allergic-type reactions[Ref]


1. "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals (2008):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.