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Silodosin Side Effects

For the Consumer

Applies to silodosin: oral capsule

As well as its needed effects, silodosin may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking silodosin, check with your doctor immediately:

Less common:
  • Chills
  • cold sweats
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Incidence not known:
  • Abdominal or stomach pain
  • clay-colored stools
  • dark urine
  • fever
  • headache
  • itching
  • loss of appetite
  • nausea
  • pinpoint red or purple spots on the skin
  • rash
  • skin blisters
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Minor Side Effects

Some silodosin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Change or problem with discharge of semen
Less common:
  • Diarrhea
  • muscle aches
  • sore throat
  • stuffy or runny nose

For Healthcare Professionals

Applies to silodosin: oral capsule


The most common adverse reaction was retrograde ejaculation.[Ref]


Very common (10% or more): Retrograde ejaculation (28.1%)
Common (1% to 10%): Prostate-specific antigen (PSA) increased
Uncommon (0.1% to 1%): Priapism[Ref]


Common (1% to 10%): Nasopharyngitis, nasal congestion, sinusitis, rhinorrhea
Postmarketing reports: Pharyngeal edema[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Syncope[Ref]


Common (1% to 10%): Diarrhea, abdominal pain
Postmarketing reports: Swollen tongue[Ref]


Common (1% to 10%): Orthostatic hypotension[Ref]


Common (1% to 10%): Asthenia[Ref]


Common (1% to 10%): Insomnia[Ref]


Frequency not reported: Intraoperative floppy iris syndrome[Ref]


Postmarketing reports: Toxic skin eruption, purpura, skin rash, pruritus, urticaria[Ref]


Postmarketing reports: Jaundice, hepatic function impaired, transaminases increased[Ref]


Postmarketing reports: Allergic-type reactions[Ref]


1. "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals, Corona, CA.

It is possible that some side effects of silodosin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.