Orlistat Alternatives Compared
| Orlistat | Wegovy (semaglutide) | Phentermine |
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| Orlistat | Wegovy (semaglutide) | Phentermine |
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Prescription and OTC
Prescribed for Weight Loss (Obesity/Overweight), Nonalcoholic Steatohepatitis. Orlistat may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction. Wegovy may also be used for purposes not listed in this medication guide. |
Prescription only
Phentermine may be used short-term as an aid to weight loss; however, it can be addictive and tolerance may develop to its weight-losing effects, rendering it less effective with time. Prescribed for... View more |
Related suggestions Weight Loss (Obesity/Overweight)
Popular comparisons
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| More about Orlistat | More about Wegovy (semaglutide) | More about Phentermine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Orlistat has an average rating of 7.4 out of 10 from a total of 401 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 17% reported a negative effect. |
Wegovy has an average rating of 7.6 out of 10 from a total of 516 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 14% reported a negative effect. |
Phentermine has an average rating of 8.6 out of 10 from a total of 3015 ratings on Drugs.com. 82% of reviewers reported a positive effect, while 5% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Orlistat side effects |
View all Wegovy side effects |
View all Phentermine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all Orlistat prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Phentermine prices |
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| Dosage Forms | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Alli, Xenical | Other semaglutide brands include: Ozempic, Rybelsus | Adipex-P, Atti-Plex P, Lomaira | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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13.5 hours |
168 hours |
20 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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| Pregnancy Category | ||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 145 drugs are known to interact with Orlistat:
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A total of 275 drugs are known to interact with Wegovy:
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A total of 196 drugs are known to interact with Phentermine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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April 23, 1999 |
N/A |
August 14, 1973 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.