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Orlistat and Constipation: What Users Say

Brand names: Xenical, Alli

Constipation: mentioned by 13 users (3.3%)

Based on user experiences from 400 Orlistat reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

diarrhea 11.0%
gas 5.0%
upset stomach 5.0%
constipation 3.3%
bloating 1.8%
oily skin 1.5%
cramps 1.3%
headaches 1.3%
liver damage 1.0%
bowel movements 0.8%

Reviews for Orlistat

Commonly mentioned side effects
  • Bab...
  • Taken for 1 to 6 months
  • April 15, 2018

Orlistat for Weight Loss (Obesity/Overweight) "I almost decided not to try Alli because of the horror stories, but I'm glad I did. The first two days I had minor nausea and slight cramping, but it never recurred after that. I have followed the diet and fat requirements, and I have never had an accident or any problems, I am on week 4. The only slight day-to-day issue is minor constipation and a little gas. Not enough to make me stop taking it. I ate in a restaurant for the first time and did not have access to nutrition content and had no issues. If you are serious about diet and weight loss, give it a try and don't let the horror stories deter you."

9 / 10
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170 Report
  • Mrs...
  • November 7, 2016

Orlistat for Weight Loss (Obesity/Overweight) "I used Alli because I wanted to lose weight but needed help with commitment to my diet. It's been about a week and I lost 5 lbs. Surprisingly, it helped with my bloating and constipation, which may also be why I lost 5 lbs in a week. Not looking for a miracle pill, just something to help out, like a guard rail at the bowling alley. You may not get a strike, but at least you didn't get a gutter ball! lol"

10 / 10
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119 Report
  • Ver...
  • Taken for less than 1 month
  • March 13, 2016

Orlistat for Weight Loss (Obesity/Overweight) "I started taking Alli February 18, 2016. I've lost 9 lbs so far (3 weeks)! Week one, I did not change my eating habits, but I could tell the pills were working due to frequent visits to the restroom. Week two, I started eating healthier and noticed that I wasn't using the bathroom as much. I did not rate Alli a 10 because I was constipated for 2 days, although it could be due to the fact that I am no longer eating greasy foods like I was during week one. Overall, I love Alli, and it is really working for me. Losing those 9 lbs motivated me to keep going!"

9 / 10
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83 Report

Frequently asked questions

  • Blu...
  • Taken for less than 1 month
  • February 21, 2020

For Weight Loss (Obesity/Overweight) "I started orlistat 2 days ago. Nothing happened the first two days. Was a little constipated, and due to reading all the reviews of uncontrollable stools, I rushed out and bought Tena Discreet, which I've not needed so far! Today I had my first noticeable stool with orange-like liquid when wiping, and the fat was noticeable in the bowl, like if you were to drop oil into water. Had no discomfort, lost 1 lb so far, only taking with food or prior to food as advised. Looking forward to the results, carrying on, not expecting miracles in 1 week. Stay realistic and don't wish for side effects. Just because you don't have side effects doesn't mean it's not working."

8 / 10
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43 Report
  • hsi...
  • April 26, 2016

Orlistat for Weight Loss (Obesity/Overweight) "I purchased Alli back in 2009 (great worked a treat and lost weight), and since I have had two more attempts in 2014, now 2016. The product does not work at all. This time I have been taking it for over one week, and I have experienced constipation and flatulence. The product was purchased from reputable pharmacies, and again I feel I just wasted my hard-earned money. I am unsure what has changed. However, I know one thing: the product is definitely not the same, I feel like the tablets are duds. No change to my weight, just embarrassing wind, stomach cramps, it makes you feel bunged up. No change to stool whatsoever, not even if fatty food is introduced to the diet. My advice is do not bother, I won't from now on. Hope this helps :("

1 / 10
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73 Report

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  • Rob...
  • Taken for 6 months to 1 year
  • January 15, 2019

Orlistat for Weight Loss (Obesity/Overweight) "I am not obese, just wanted to lose 20 lbs that I have not had luck shedding over the years. I have been taking Alli for 3 months now and have not lost any weight. It did, however, help me from being constipated. If you're having trouble pooping, Alli will help."

5 / 10
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33 Report
  • MB2...
  • Taken for less than 1 month
  • January 28, 2023

Orlistat for Weight Loss (Obesity/Overweight) "Started taking Xenical 1 week ago and lost 7 lbs in one week. Haven’t yet had any form of accidents, however, I have completely changed my diet to low fat and added 45 minutes of walking 5 days a week. I did experience headaches for a few days, which have now completely passed. I have been eating 1,200 calories daily (roughly) and found this to help. Have also experienced constipation if taken with a meal that’s between 2-5 g of fat."

10 / 10
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8 Report
  • Fai...
  • Taken for 1 to 6 months
  • June 11, 2019

Orlistat for Weight Loss (Obesity/Overweight) "The new generation of Orlistat, sold over the counter as Alli, does NOT work. I was on Xenical when it first came out in the 1990s. It worked very well, and the orange discharge was a daily thing. Now, 4 months ago, I purchased Alli over the counter. Paid $85 and was very disappointed to find out that I had wasted my money. First, each pill is filled only 60 mg instead of the Xenical, which is 120 mg, so it is not the same dose. Second, even when doubling up doses, it still does not grab the fat and produce the orange discharge like the old ones used to. I will never purchase this again. It is basically a placebo. I tried the keto diet for a while to help with weight loss, but the constipation and limitations were so horrible it didn't work. I also tried Phentermine, and it too was unsuccessful in the long run. What works? The MY PLATE model, using a toddler-sized sectioned plate."

1 / 10
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67 Report
  • bee...
  • May 20, 2018

For Weight Loss (Obesity/Overweight) "I started orlistat almost 2 weeks ago and did lose 6 lbs, but I am very, very constipated. I'm not sure if it was the pill or my IBS (irritable bowel syndrome) acting up again. Once I got that under control, now there is lots of restroom time, no leaky stool, or wet farts. I do have lots of cramping and gurgling, but it's tolerable. I do walk but have a bad foot... waiting on x-rays. I guess I'm going to have to do other things not to injure it more."

7 / 10
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7 Report
  • Bar...
  • Taken for 1 to 6 months
  • December 25, 2024

For Weight Loss (Obesity/Overweight) "So I was a little skeptical. Initially, I wanted a prescription of Ozempic, but orlistat was the best thing I could get and a fraction of the price. I got the drug and read what it did. I was a little disappointed, to say the least. However, I gave it a shot. I’ve been constipated for most of my life and taken laxatives as an adult - it got worse after the birth of my first child. I felt like my constipation got worse in the first week or two of taking the drug and even reported to a girlfriend that it was no good, it made me worse. However, I stuck with it - and after two weeks, I actually started to feel better. I had improved energy, I go to the toilet frequently, although a bit runny, and have to clean the bowl all the time as fecal matter is quite orange and stains the porcelain. And after about seven weeks, I can say I’ve lost a couple of kilos at least. So I love orlistat, the hardest part is remembering to take it before meals three times a day. But it is forgiving if you do miss a dose."

9 / 10
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0 Report
  • Anonymous
  • Taken for 10 years or more
  • June 27, 2016

For Weight Loss (Obesity/Overweight) "The following are the scary details of my experience: 1. Headaches at the top right of my head. 2. Muscle cramps in my calves. 3. Constipation. 4. Frequently wanting to urinate. The output was about two tablespoons, followed by severe tingling in both arms (I tolerated it for 2 days). This item #4 became scary. I came to this website, read the reviews, and threw the rest of the pills in the garbage."

1 / 10
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5 Report
  • Aja...
  • Taken for 1 to 6 months
  • June 10, 2019

For Weight Loss (Obesity/Overweight) "This medicine is a lifesaver. I was up to 200 lbs in January 2019. Today I’m down to 174. Plus, I struggled with severe constipation for years. I now just go once a day. This medicine is wonderful."

10 / 10
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38 Report
  • Ano...
  • Taken for less than 1 month
  • May 14, 2017

Orlistat for Weight Loss (Obesity/Overweight) "Well, I've been taking orlistat for 6 days, three times a day, and already lost 1 kg. Although I have a headache and am slightly constipated, I am happy I have found something that works."

8 / 10
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26 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.