NovoLog PenFill Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
NovoLog PenFill (insulin aspart)	Rybelsus (semaglutide)	Mounjaro (tirzepatide)	Enter another drug to compare

NovoLog PenFill (insulin aspart)

Rybelsus (semaglutide)

Mounjaro (tirzepatide)

Prescription only

Prescribed for Type 2 Diabetes, Diabetic Ketoacidosis, Diabetes - Type 1, Nonketotic Hyperosmolar Syndrome. NovoLog PenFill may also be used for purposes not listed in this medication guide.

Prescription only

Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

More about NovoLog PenFill (insulin aspart)

More about Rybelsus (semaglutide)

More about Mounjaro (tirzepatide)

Ratings & Reviews

Be the first to share your experience with this drug.

Rybelsus has an average rating of 6.4 out of 10 from a total of 312 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1450 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

Review this drug

View all 312 reviews

View all 1450 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all NovoLog PenFill side effects

Nausea (40.4%)
Diarrhea (20.8%)
Constipation (17.3%)
Loss of appetite (9.3%)
Vomiting (8.3%)
Stomach pain (5.4%)
Upset stomach (5.1%)

View all Rybelsus side effects

Nausea (16.3%)
Constipation (11.7%)
Diarrhea (8.2%)
Loss of appetite (4.6%)
Upset stomach (4.5%)
Vomiting (4.5%)
Burping (3.9%)

View all Mounjaro side effects

Drug Class

Insulin

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

N/A

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	15 mL
Strength	100 units/mL
Per unit^*	$9.28
Cost^*	$139.15

View all NovoLog PenFill prices

Quantity	30 tablet
Strength	3 mg
Per unit^*	$32.74
Cost^*	$982.34

View all Rybelsus prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$531.31
Cost^*	$1,062.62

View all Mounjaro prices

Get free Discount Card

Dosage Forms

Injectable solution

Oral tablet

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.5 hours

168 hours

120 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 396 drugs are known to interact with NovoLog PenFill:

16 major drug interactions (41 brand and generic names)
359 moderate drug interactions (1894 brand and generic names)
21 minor drug interactions (210 brand and generic names)

A total of 275 drugs are known to interact with Rybelsus:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 416 drugs are known to interact with Mounjaro:

16 major drug interactions (37 brand and generic names)
399 moderate drug interactions (2282 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

N/A

September 20, 2019

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Rybelsus uses

Mounjaro uses

Professional Resources

N/A

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

NovoLog PenFill Alternatives Compared

See also:

Ozempic

Rybelsus

Mounjaro

Trulicity

Lantus

Tresiba

Levemir

Victoza

Basaglar

Novolog

Further information

NovoLog PenFill Alternatives Compared

See also:

Further information

Compare Drugs