Comparing Naprosyn vs Arthrotec

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naprosyn (naproxen)	Arthrotec (diclofenac / misoprostol)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naprosyn (naproxen)	Arthrotec (diclofenac / misoprostol)	Enter another drug to compare
Prescription and OTC Prescribed for Back Pain, Ankylosing Spondylitis, Bursitis, Aseptic Necrosis, Muscle Pain, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever... View more	Prescription only Prescribed for Sciatica, Osteoarthritis, Rheumatoid Arthritis. Arthrotec may also be used for purposes not listed in this medication guide.	Related suggestions Osteoarthritis Meloxicam Celebrex Diclofenac Celecoxib Hyaluronan Ibuprofen Rheumatoid Arthritis Methotrexate Humira Hydroxychloroquine Prednisone Meloxicam Celebrex Sciatica Cyclobenzaprine Naproxen Diclofenac Ibuprofen Acetaminophen Tylenol Popular comparisons Naprosyn vs naproxen
More about Naprosyn (naproxen)	More about Arthrotec (diclofenac / misoprostol)
Ratings & Reviews
Naprosyn has an average rating of 6.8 out of 10 from a total of 33 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 21% reported a negative effect.	Arthrotec has an average rating of 8.4 out of 10 from a total of 44 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 7% reported a negative effect.
View all 33 reviews	View all 44 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
View all Naprosyn side effects	View all Arthrotec side effects
Drug Class
Nonsteroidal anti-inflammatory drugs	Nonsteroidal anti-inflammatory drugs
Generic Availability
Lower cost generic approved	Lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral suspension Oral tablet	Oral delayed release tablet Oral tablet
Brand Names
Other naproxen brands include: Aflaxen, Aleve, Aleve Back and Muscle Pain, All Day Pain Relief, All Day Relief, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naproxen Sodium DS, Pamprin All Day Relief View more	N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
18 hours	2 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	X Category X Not for use in pregnancy See the full pregnancy warnings document.
Drug Interactions
A total of 474 drugs are known to interact with Naprosyn: 101 major drug interactions (447 brand and generic names) 346 moderate drug interactions (1389 brand and generic names) 27 minor drug interactions (152 brand and generic names)	A total of 466 drugs are known to interact with Arthrotec: 103 major drug interactions (433 brand and generic names) 339 moderate drug interactions (1343 brand and generic names) 24 minor drug interactions (260 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more	Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more
Disease Interactions
Asthma Fluid retention GI toxicity Rash Renal toxicities Thrombosis Sodium Anemia Hepatotoxicity Hyperkalemia Platelet aggregation inhibition	Asthma Fluid retention GI toxicity Rash Renal toxicities Thrombosis Porphyria Cardiovascular disease Diarrhea Anemia Hepatotoxicity Hyperkalemia Platelet aggregation inhibition
First Approval Date
March 11, 1976	December 24, 1997
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español	Side effects Drug interactions Dosage Pricing and coupons Pregnancy warnings Drug images En español
Patient Resources
Naprosyn uses	Arthrotec uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Back Pain Ankylosing Spondylitis Bursitis Aseptic Necrosis Muscle Pain Chronic Myofascial Pain Costochondritis Diffuse Idiopathic Skeletal Hyperostosis Dysautonomia Fever Frozen Shoulder Gout - Acute Headache Neck Pain Osteoarthritis Pain Period Pain Polyarticular Juvenile Idiopathic Arthritis Rheumatoid Arthritis Sciatica Spondylolisthesis Tendonitis show all	Sciatica Osteoarthritis Rheumatoid Arthritis

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

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Medical Disclaimer

Comparing Naprosyn vs Arthrotec

See also:

Humira

Taltz

Cosentyx

Paracetamol

Tylenol

Cymbalta

Oxycodone

Cyclobenzaprine

Tramadol

Duloxetine

Further information