Comparing Midazolam vs Propofol

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Midazolam	Propofol	Enter another drug to compare

Midazolam

Propofol

Prescription only

Prescribed for Light Sedation, ICU Agitation, Seizures, Light Anesthesia, Status Epilepticus. Midazolam may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Anesthesia. Propofol may also be used for purposes not listed in this medication guide.

More about Midazolam

More about Propofol

Ratings & Reviews

Midazolam has an average rating of 4.6 out of 10 from a total of 147 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 56% reported a negative effect.

Propofol has an average rating of 7.5 out of 10 from a total of 414 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 147 reviews

View all 414 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Memory loss (9.5%)
Anxiety (7.5%)
Dizziness (6.8%)
Pain (6.8%)
Drowsiness (6.1%)
Vomiting (6.1%)
Nausea (3.4%)

View all Midazolam side effects

Drowsiness (13.5%)
Burning (9.9%)
Sneezing (9.4%)
Nausea (8.7%)
Runny nose (7.7%)
Sore throat (6.5%)
Dizziness (6.0%)

View all Propofol side effects

Drug Class

Benzodiazepines

General anesthetics

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	25 mL
Strength	5 mg/mL
Per unit^*	$0.84
Cost^*	$21.08

View all Midazolam prices

Quantity	200 mL
Strength	10 mg/mL
Per unit^*	$0.14 - $0.30
Cost^*	$28.31 - $60.40

View all Propofol prices

Get free Discount Card

Dosage Forms

Injectable solution
Intravenous solution
Oral syrup

Intravenous emulsion

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4 hours

CSA Schedule ¹ View glossary of CSA terms

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 577 drugs are known to interact with Midazolam:

60 major drug interactions (244 brand and generic names)
476 moderate drug interactions (1736 brand and generic names)
41 minor drug interactions (337 brand and generic names)

A total of 365 drugs are known to interact with Propofol:

19 major drug interactions (55 brand and generic names)
339 moderate drug interactions (1351 brand and generic names)
7 minor drug interactions (54 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous side... View more

Alcohol can increase the nervous system side effects of propofol such as dizziness, drowsiness, and... View more

Disease Interactions

First Approval Date

October 15, 1998

October 02, 1989

WADA Class View classifications

N/A

More Information

Patient Resources

Propofol uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Midazolam vs Propofol

See also:

Lamictal

Lyrica

Ozempic

Depakote

Ativan

Keppra

Klonopin

Topamax

Valium

Neurontin

Further information

Comparing Midazolam vs Propofol

See also:

Further information

Compare Drugs