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Propofol Disease Interactions

There are 5 disease interactions with propofol.


Propofol (applies to propofol) cardiovascular dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder, Hypotension, Heart Block, Ischemic Heart Disease, Tachyarrhythmia

Propofol can induce severe hypotension and/or cardiovascular depression, particularly during the induction phase of sedation or anesthesia. Use of propofol infusions for both adult and pediatric ICU sedation has been associated with a constellation of metabolic derangements and organ system failures, referred to as Propofol Infusion Syndrome, that have resulted in death. The syndrome is characterized by severe metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis,hepatomegaly, renal failure, ECG changes (ST segment elevation similar to that in Brugada syndrome) and/or cardiac failure. Therapy with propofol should be administered cautiously in patients with preexisting cardiovascular disorders, hemodynamic impairment, increased intracranial pressure, or impaired cerebral circulation.


  1. Deutschman CS, Harris AP, Fleisher LA "Changes in heart rate variability under propofol anesthesia: a possible explanation for propofol-induced bradycardia." Anesth Analg 79 (1994): 373-7
  2. Warden JC, Pickford DR "Fatal cardiovascular collapse following propofol induction in high-risk patients and dilemmas in the selection of a short-acting induction agent." Anaesth Intensive Care 23 (1995): 485-7
  3. "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals (2001):
  4. Mackay P "Fatal cardiovascular collapse following propofol induction in high-risk patients." Anaesth Intensive Care 24 (1996): 125-6
View all 4 references

Propofol (applies to propofol) hyperlipidemia

Moderate Potential Hazard, High plausibility.

Propofol is formulated in an oil-and-water emulsion and elevated triglycerides can occur during extended therapy. Propofol should be administered cautiously in patients with lipid disorders such as primary hyperlipoproteinemia, diabetic hyperlipemia, and pancreatitis. Each milliliter of propofol contains 0.1g of fat (1.1 kcal).


  1. "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals (2001):
  2. Mateu J, Barrachina F "Hypertriglyceridaemia associated with propofol sedation in critically ill patients." Intensive Care Med 22 (1996): 834-5

Propofol (applies to propofol) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

At high doses (2-3 grams per day), EDTA has been reported, on rare occasions, to be toxic to the renal tubules. Studies to-date, in patients with normal or impaired renal function have not shown any alteration in renal function with propofol Injectable Emulsion containing 0.005% disodium edetate. In patients at risk for renal impairment, urinalysis and urine sediment should be checked before initiation of sedation and then be monitored on alternate days during sedation.


  1. "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals (2001):

Propofol (applies to propofol) seizure

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Seizures

Patients with seizure disorders are at increased risk of seizure activity during the recovery phase of sedation or anesthesia following administration of propofol. Clinical monitoring of seizure activity is recommended in patients with or predisposed to seizure disorders.


  1. DeFriez CB, Wong HC "Seizures and opisthotonos after propofol anesthesia." Anesth Analg 75 (1992): 630-2
  2. Sutherland MJ, Burt P "Propofol and seizures." Anaesth Intensive Care 22 (1994): 733-7
  3. Samra SK, Sneyd JR, Ross DA, Henry TR "Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy." Anesthesiology 82 (1995): 843-51
  4. "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals (2001):
  5. Cochran D, Price W, Gwinnutt CL "Unilateral convulsion after induction of anaesthesia with propofol." Br J Anaesth 76 (1996): 570-2
  6. Harrigan PWJ, Browne SM, Quail AW "Multiple seizures following re-exposure to propofol." Anaesth Intensive Care 24 (1996): 261-4
View all 6 references

Propofol (applies to propofol) zinc deficiency

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Sepsis, Burns - External

Reports of mean urinary zinc loss during propofol therapy was approximately 2.5 to 3.0 mg/day in adult patients and 1.5 to 2.0 mg/day in pediatric patients. Practitioners should consider the administration of supplemental zinc during prolonged therapy with propofol in patients who are predisposed to zinc deficiency, such as those with burns, diarrhea, and/or major sepsis. Monitoring is recommended in these patients.


  1. "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals (2001):

Propofol drug interactions

There are 337 drug interactions with propofol.

Propofol alcohol/food interactions

There are 2 alcohol/food interactions with propofol.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.