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Propofol Pregnancy and Breastfeeding Warnings

Propofol is also known as: Diprivan, Propoven

Medically reviewed on Feb 2, 2017

Propofol Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk; some manufacturers consider this drug to be contraindicated in pregnancy.

AU TGA pregnancy category: C
US FDA pregnancy category: B

-Animal studies have shown some evidence of delayed ossification or abnormal cranial ossification with an increase in the incidence of subcutaneous hematomas. There are no adequate and well-controlled studies in pregnant women.
-This drug should not be used for obstetric anesthesia because it crosses the placenta and may be associated with neonatal depression.

AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Propofol Breastfeeding Warnings

-Amounts of this drug in milk are very small and are not expected to be absorbed by the infant.
-Some experts recommend that women should not breastfeed for 24 hours after administration of this drug and any milk produced during this period should be discarded; however, others say that breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse and that discarding milk is unnecessary.
-When a combination of anesthetic agents is used for a procedure, the recommendations for the most problematic medication used during the procedure should be followed.
-General anesthesia for cesarean section using this drug as a component for induction may delay the onset of lactation.

Use is not recommended; some manufacturers consider this drug to be contraindicated in lactation.

Excreted into human milk: Yes (in small amounts)

Comment:
-The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
  3. Cerner Multum, Inc. "Australian Product Information." O 0
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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