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Generic Name: propofol (PROE poe fol)
Brand Names: Diprivan, Propoven

What is propofol?

Propofol (Diprivan) slows the activity of your brain and nervous system.

Propofol is used to help you relax before and during general anesthesia for surgery or other medical procedures.

Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).

Important information

Before you receive propofol, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use propofol.

Before receiving this medicine

You should not receive propofol if you are allergic to it.

To make sure this medicine is safe for you, tell your doctor if you have:

  • epilepsy or other seizure disorder; or

  • high cholesterol or triglycerides (a type of fat in the blood).

Anesthesia medicine may affect brain development in a child under 3, or an unborn baby whose mother receives this medicine during late pregnancy. These effects may be more likely when the anesthesia is used for 3 hours or longer, or used for repeated procedures. Effects on brain development could cause learning or behavior problems later in life.

Negative brain effects from anesthesia have been seen in animal studies. However, studies in human children receiving single short uses of anesthesia have not shown a likely effect on behavior or learning. More research is needed.

In some cases, your doctor may decide to postpone a surgery or procedure based on these risks. Treatment may not be delayed in the case of life-threatening conditions, medical emergencies, or surgery needed to correct certain birth defects.

Ask your doctor for information about all medicines that will be used during your surgery or procedure. Also ask how long the procedure will last.

Propofol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How is propofol given?

Propofol is injected into a vein through an IV. A healthcare provider will give you this injection.

You will relax and fall asleep very quickly after propofol is injected.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are under the effects of propofol.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Since propofol is given by a healthcare professional in a medical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving propofol?

Propofol can cause severe drowsiness or dizziness, which may last for several hours. You will need someone to drive you home after your surgery or procedure. Do not drive yourself or do anything that requires you to be awake and alert for at least 24 hours after you have been treated with propofol.

Propofol side effects

Get emergency medical help if you have any signs of an allergic reaction to propofol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • a light-headed feeling (like you might pass out) even after feeling awake;

  • weak or shallow breathing; or

  • severe pain or discomfort where the injection is given.

Common propofol side effects may include:

  • mild itching or rash;

  • fast or slow heart rate; or

  • slight burning or stinging around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Propofol dosing information

Usual Adult Dose for Anesthesia:

Less than 55 years: Anesthetic Induction: 40 mg IV every 10 seconds until induction onset. Total dose required is 2 to 2.5 mg/kg with a maximum of 250 mg.

Less than 55 years: Maintenance of Anesthesia: IV infusion: 100 to 200 mcg/kg/min. Maximum dose 20,000 mcg/min. Maximum dose 10,000 mcg/min.
Intermittent bolus: 20 to 50 mg as needed.

Cardiac Anesthesia: Induction: 20 mg every 10 seconds until induction onset (0.5 to 1.5 mg/kg).
Maintenance: Opioids are generally combined with propofol for maintenance of anesthesia.
100 to 150 mcg/kg/min (primary propofol)
50 to 100 mcg/kg/min (secondary propofol).
Maximum dose of 15,000 mcg/min.

Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg).
Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min.
Intermittent IV bolus doses of 0.3 to 0.7 mg/kg mg may be given for maintenance of anesthesia while on nitrous oxide.

ICU Sedation: Initial Continuous IV: 5 mcg/kg/min for intubated mechanically ventilated patients.
Maintenance Continuous IV: May increase in 5 to 10 mcg/kg/min increments every 5 minutes until the desired level of sedation is achieved. Typical maintenance range is 5 to 50 mcg/kg/min.
Bolus administration of 10 to 20 mg should only be used to rapidly increase depth of sedation in patients where hypotension is not likely to occur.

MAC sedation: Initial Continuous IV: 100 to 150 mcg/kg/min for 3 to 5 minutes or
Slow IV: 0.5 mg/kg over 3 to 5 minutes followed by:
Maintenance IV infusion: 25 to 75 mcg/kg/min (preferred) or
incremental bolus doses of 10 to 20 mg.

Usual Geriatric Dose for Anesthesia:

Elderly, debilitated, or ASA III/IV patients.
Induction: 20 mg every 10 seconds until induction onset (1-1.5 mg/kg). Maximum dose 200 mg
Maintenance: 50-100 mcg/kg/min.
MAC sedation: The maintenance dose is usually 80% of the usual adult dose.

Usual Pediatric Dose for Anesthesia:

3 years to 16 years: Induction: 2.5 to 3.5 mg/kg over 20 to 30 seconds.
Maintenance: 125 to 300 mcg/kg/min.

What other drugs will affect propofol?

Taking other medicines that make you sleepy or slow your breathing can worsen these effects. After you have been treated with propofol, ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about propofol.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 2.02. Revision Date: 2017-02-02, 5:02:34 PM.