Comparing Medroxyprogesterone vs Progesterone

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Medroxyprogesterone

Progesterone

Prescribed for Abnormal Uterine Bleeding, Amenorrhea, Endometrial Cancer, Endometrial Hyperplasia - Prophylaxis, Birth Control, Endometriosis. May also be prescribed off label for Gender Dysphoria... View more

Progesterone is a hormone that is used to treat female conditions associated with ovulation, fertility, menstruation, menopause, or abnormal uterine bleeding. It may increase the risk of blood clots... View more

Prescription only

Prescription and OTC

Commonly reported side effects include: abdominal cramps, depression, dizziness, and headache.

See the full progesterone side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	1 mL
Dosage	150 mg/mL
Per Unit^*	$44.58 - $68.45
Cost^*	$44.58 - $68.45

View all medroxyprogesterone prices

Quantity	30 capsule
Dosage	100 mg
Per Unit^*	$0.60
Cost^*	$18.03

View all progesterone prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Intramuscular suspension
Oral tablet

Intramuscular solution
Oral capsule

Brand Names

Depo-Provera, depo-subQ provera 104, Provera Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

401 hours

1 hour

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Category B No proven risk in humans

Oral Formulations

Category N Not classified

Excluding Oral Formulations

See the full Pregnancy Warnings document.

Drug Interactions

A total of 205 drugs are known to interact with medroxyprogesterone:

18 major drug interactions (47 brand and generic names)
180 moderate drug interactions (575 brand and generic names)
7 minor drug interactions (24 brand and generic names)

A total of 169 drugs are known to interact with progesterone:

3 major drug interactions (35 brand and generic names)
159 moderate drug interactions (481 brand and generic names)
7 minor drug interactions (14 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Grapefruit juice may increase the blood levels of certain medications such as progesterone. You... View more

Disease Interactions

First Approval Date

June 18, 1959

November 01, 1974

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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