Comparing Lyrica vs Topamax
| Lyrica Remove Lyrica from your drug comparison | Topamax Remove Topamax from your drug comparison |
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| Lyrica pregabalin Remove Lyrica from your drug comparison | Topamax topiramate Remove Topamax from your drug comparison | ||||||||||||||||
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Lyrica can help relieve nerve pain and control seizures but it is likely to cause drowsiness. Prescribed for Neuropathic Pain, Fibromyalgia, Diabetic Peripheral Neuropathy, Neuralgia, Postherpetic... View more |
Topamax may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraine. Drowsiness is a... View more |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.5
For Fibromyalgia: I have just started started on Lyrica 75 mg. Taking it once in the night. It seems to be working. My pain is down a bit and am able to do a lot more work than before. Also don't get as tired as before. Just got back from visiting turkey and the week I spent there was hectic. Lots and lots of walking. Don't think I would have been able to do it without this medication. I have fibromyalgia since the last 2 and half years and had shyed away from this medication because of the side effects. However I was in so much pain a month ago that I finally decided to give it a try. I don't regret it and am hoping that the effect of the medicine will last. And I'll have a normal life again. |
6.3
For Migraine Prevention: I took Topamax as much as 300mg/day for 15 years and my last dose was 150mg at night. I recently changed to Lyrica which is also an anti-convulsant and am taking 100mg/day and find it more effective than Topamax without the memory and lost word problems. I discontinued Topamax because it slowly got to the point where I could not remember something for an hour. Topamax also was causing erectile dysfunction problems for the last 3 years. I do not have this problem with Lyrica. In the end I was getting 5 or more migraines a week and now get 2 or 3 a week and expect to increase Lyrica to 300mg/day. For Migraine Prevention: I had migraines that lasted up to nine days. My neurologist started me on 25mg Topamax and the frequency dropped off immediately. I actually loved the way I felt on Topamax. I had boundless energy, no appetite, and was always in a good mood. After two years, I decided to stop taking it because my skin was breaking out and I think I felt a little too confident in myself. I drove a little faster, said really odd things to people (no filter) and seemed to be turning into a show off about how skinny I was. Not my best personality! I stopped taking it and didn't gain any weight, but the headaches are back. Once my dermatologist gets my skin cleared up, I might go back on it, but will be very mindful of the side effects. |
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Drug Class |
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Side Effects |
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Common side effects include: infection, ataxia, blurred vision, constipation, diplopia, dizziness, drowsiness, fatigue, headache, peripheral edema, tremor, weight gain, visual field loss, accidental injury, and xerostomia. See the full Lyrica side effects document. |
Common side effects include: anxiety, ataxia, confusion, diarrhea, diplopia, dizziness, drowsiness, dysphasia, fatigue, lack of concentration, memory impairment, nausea, nervousness, paresthesia, psychomotor disturbance, speech disturbance, depression, visual disturbance, weight loss, dysgeusia, mood changes, and anorexia. See the full Topamax side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all Lyrica prices and generic prices |
View all Topamax prices and generic prices |
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Generic Availability |
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Dosage Form(s) Available |
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Brand Names |
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| Other pregabalin brands include: Lyrica CR | Other topiramate brands include: Qudexy XR, Trokendi XR | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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6.3 hours |
56 hours |
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CSA Schedule**View glossary of terms. |
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 267 drugs are known to interact with Lyrica:
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A total of 264 drugs are known to interact with Topamax:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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December 30, 2004 |
December 24, 1996 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Fibromyalgia: I’m on a set dose of Lyrica 150mg 2x a day, then 300mg at night. It has been amazing for my pain! I also suffer from Lupus, and Sjogren's. I’m better as long as I take my medicine!