Comparing Cymbalta vs Lyrica
| Cymbalta | Lyrica |
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| Cymbalta (duloxetine) | Lyrica (pregabalin) |
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Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Prescription only
Lyrica can help relieve nerve pain and control seizures but it is likely to cause drowsiness. Prescribed for Neuropathic Pain, Diabetic Peripheral Neuropathy, Fibromyalgia, Neuralgia, Postherpetic... View more |
Related suggestions Fibromyalgia
Diabetic Peripheral Neuropathy
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| More about Cymbalta (duloxetine) | More about Lyrica (pregabalin) | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Cymbalta has an average rating of 6.2 out of 10 from a total of 1814 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
Lyrica has an average rating of 6.4 out of 10 from a total of 910 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 27% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Common side effects include:
See also: Cymbalta side effects in more detail. |
Common side effects include:
See also: Lyrica side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Cymbalta prices and generic prices |
View all Lyrica prices and generic prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other duloxetine brands include: Drizalma Sprinkle, Irenka | Other pregabalin brands include: Lyrica CR | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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17 hours |
6.3 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 576 drugs are known to interact with Cymbalta:
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A total of 280 drugs are known to interact with Lyrica:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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N/A |
December 30, 2004 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.