Comparing Lupron Depot vs Zoladex
Lupron Depot Remove Lupron Depot from your drug comparison | Zoladex Remove Zoladex from your drug comparison |
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Lupron Depot leuprolide Remove Lupron Depot from your drug comparison | Zoladex goserelin Remove Zoladex from your drug comparison | ||||||||||||||||
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Lupron Depot is a hormone deprivation treatment that may be used for the palliative care of advanced prostate cancer. The main side effects are hot flushes and general pain and it may cause... View more |
Prescribed for Prostate Cancer, Endometriosis, Breast Cancer - Palliative, Bleeding Disorder. Zoladex may also be used for purposes not listed in this medication guide. |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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5.7
For Endometriosis: I had a very similar experience to Lora C. I was a mess on Lupron and very much not myself. I couldn't control my emotions, I was either dead inside or crying, there was no in between. My night sweats were awful and I was mean all the time. The worst part was probably my memory. I had no recollection of anyone's name, I could recognize their face and the fact that I definitely know them, but never their names if I had met them after I was on Lupron. The shot also hurts like anything and hot flashes are real. I was consistently warm all of the time. Summer was unbearable. Also, the first few months were the worst endo pain I had ever felt. It was terrible. It finally went away after about month 4 or 5 and I was in a normal range of just feeling pressure down there. It wasn't nearly as painful, but always present. |
6.8
For Endometriosis: I have stage 4 endometriosis and have had laproscopic surgery to remove it from my pelvis/abdomen but I also have it throughout my bowel and it has penetrated all the way through. My doctor has put me on Zoladex for 9 months and I am on month 4. It has helped to manage my pain so far, initially it had taken virtually all of the pain away but within the last month it has slowly been resurfacing but it is still better than when I don't take it at all. The hot flashes, flushing, slight weight gain, night sweats, trouble sleeping, muscle aches, moodiness, anxiety, vaginal dryness and lack of sex drive are all bothersome but it beats being in constant pain and I know that the symptoms are temporary. I would definitely recommend Zoladex for endometriosis pain. For Endometriosis: I have used Zoladex 3 month implant for 9 months, as I suffer from Pulmonary Endometriosis. Zoladex was the only medication that successfully stopped my periods, and to stop my lungs collapsing every cycle. Positives would be no mood swings, clear skin, and no periods therefore no pain. Negatives would be I gained 10 kilos, which I'm working on losing, but the weight was better than having horrific lung pain. I did have a small amount of bone pain, but this has stopped since I've been off the medication for a month. The other negative is its only subsidized in some parts of Australia. One state its $25 the other $1000 for three months. I hope this helps. In many ways Zoladex has helped me live a normal life again. |
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Drug Class |
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Side Effects |
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See the full Lupron Depot side effects document. |
Common side effects include: headache, vasodilation, and diaphoresis. See the full Zoladex side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all Lupron Depot prices and generic prices |
View all Zoladex prices |
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Generic Availability |
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No |
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Dosage Form(s) Available |
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Brand Names |
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Other leuprolide brands include: Eligard, Fensolvi, Lupron Depot-PED | Other goserelin brands include: Zoladex 3-Month | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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4.25 hours |
4.2 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
N/A |
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Drug Interactions |
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A total of 256 drugs are known to interact with Lupron Depot:
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A total of 258 drugs are known to interact with Zoladex:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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January 26, 1989 |
December 29, 1989 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Endometriosis: I've finished my third cycle of lupron for endometriosis and it kicked my butt ! Each cycle includes an injection each month, for 6 months. Once I finish Lupron, I slowly have periods and each month the pain gets stronger. Last time was bad, but nothing like this. There's no way of describing it other then "Roid rage", I couldn't control my emotions. 2 1/2 months I was manic, I'm talking fighting fits of rage and sobbing on the floor. which is nothing like myself, I'm almost emotionless. Hot flashes, hair thinning, loss of sex drive. That last one which I hope doesn't affect you, surprisingly is one of the worst. Gained 30 lbs over 6 mths while dieting, Even with an extremely strict diet I have only managed to loose 2 pounds and it's been 2 and a half months since my last injection. All in all I'm not sure if I will go through another treatment of Lupron as all the side effects that affected me seem to get more intense each time.