Comparing Loperamide vs Metoclopramide

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Loperamide	Metoclopramide	Enter another drug to compare

Loperamide

Metoclopramide

Prescription and OTC

Loperamide effectively treats diarrhea in adults and children over the age of 2 years by slowing down the movement of the bowel. Children are especially sensitive to its effects, especially if they... View more

Prescription only

Metoclopramide may be used short-term for the treatment of gastrointestinal reflux disease that is unresponsive to other medications or to treat diabetic stasis. Side effects may include sedation... View more

More about Loperamide

More about Metoclopramide

Ratings & Reviews

Loperamide has an average rating of 8.4 out of 10 from a total of 93 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 10% reported a negative effect.

Metoclopramide has an average rating of 3.9 out of 10 from a total of 521 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 64% reported a negative effect.

View all 93 reviews

View all 521 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Constipation (6.5%)
Diarrhea (5.4%)
Cramps (4.3%)
Abdominal pain (3.2%)
Upset stomach (3.2%)

View all Loperamide side effects

Anxiety (35.1%)
Nausea (14.0%)
Restlessness (13.2%)
Tremors (12.9%)
Panic attacks (12.3%)
Depression (7.7%)
Vomiting (6.9%)

View all Metoclopramide side effects

Drug Class

Antidiarrheals

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	6 capsule
Strength	2 mg
Per unit^*	$1.97
Cost^*	$11.81

View all Loperamide prices

Quantity	100 each
Strength	10 mg
Per unit^*	$0.18
Cost^*	$17.56

View all Metoclopramide prices

Get free Discount Card

Dosage Forms

Oral capsule
Oral liquid
Oral suspension
Oral tablet

Injectable solution
Oral syrup
Oral tablet
Oral tablet, disintegrating

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

10.8 hours

8 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 354 drugs are known to interact with Loperamide:

44 major drug interactions (170 brand and generic names)
309 moderate drug interactions (1220 brand and generic names)
1 minor drug interactions (7 brand and generic names)

A total of 364 drugs are known to interact with Metoclopramide:

53 major drug interactions (207 brand and generic names)
300 moderate drug interactions (1495 brand and generic names)
11 minor drug interactions (417 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of loperamide such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of metoclopramide such as dizziness... View more

Disease Interactions

First Approval Date

N/A

December 30, 1980

WADA Class View classifications

N/A

More Information

Patient Resources

Loperamide uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Loperamide vs Metoclopramide

See also:

Bentyl

Xifaxan

Ozempic

Metamucil

Levsin

Librax

Hyosyne

Lotronex

Psyllium

Hyoscyamine

Further information

Comparing Loperamide vs Metoclopramide

See also:

Further information

Compare Drugs