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Metoclopramide Pregnancy and Breastfeeding Warnings

Metoclopramide is also known as: Maxolon, Metozolv ODT, Reglan

Metoclopramide Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk. AU TGA pregnancy category: A US FDA pregnancy category: B Comments: -Use during the first and third trimesters should be avoided when possible. -Monitoring for extrapyramidal syndrome is recommended for neonates exposed during the third trimester. -After delivery, mothers are at a relatively high risk for postpartum depression, and this drug can cause depression as a side effect. Therefore, therapy should probably be avoided in women with a history of major depression and not used for prolonged periods in any mother during this time of high susceptibility.

Human data (greater than 1000 outcomes) do not indicate fetotoxicity or malformative toxicity associated with therapy. Use at the end of pregnancy may result in extrapyramidal syndrome of the neonate. AU TGA pregnancy category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Metoclopramide Breastfeeding Warnings

Variable amounts are excreted in breast milk, with some infants receiving doses that achieve pharmacologically active serum levels, elevated serum prolactin and possible gastrointestinal side effects. This drug is used as a galactagogue, but its clinical value in increasing milk supply is questionable.

AU, UK: Use is not recommended. US: Use with caution. Excreted into human milk: Yes Comments: -The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):
  2. "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. Cerner Multum, Inc. "Australian Product Information." O 0

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