Metoclopramide and Depression: What Users Say

• Mil...
• October 30, 2020

Metoclopramide for Migraine "DO NOT TAKE THIS MEDICATION!!! The doctors gave me this medication without explaining to me the common side effect of basically going insane for a short period of time. They just told me I would feel 'weird' for a little bit and then it would go away. They didn’t even ask me if I had a history of mental illness. I was expecting to feel drowsy or sleepy or a bit off because that’s what feeling 'weird' is supposed to feel like. But no!!! I suffered temporary insanity!!! Extreme derealization, depersonalization, depression, hopelessness, my life felt meaningless, I felt like I was dying and kept thinking about how I did not want to die!!! I felt doomed!!! I wanted to jump out of my skin and run out of the hospital!!!! I was about to rip the IV off my arm. Tremendous emotional despair and near-death experience!!! It was a nightmare while being awake!! I would much rather have the migraine!!!"

• Mil...
• October 30, 2020

Metoclopramide for Migraine "DO NOT TAKE THIS MEDICATION!!! The doctors gave me this medication without explaining to me the common side effect of basically going insane for a short period of time. They just told me I would feel 'weird' for a little bit and then it would go away. They didn’t even ask me if I had a history of mental illness. I was expecting to feel drowsy or sleepy or a bit off because that’s what feeling 'weird' is supposed to feel like. But no!!! I suffered temporary insanity!!! Extreme derealization, depersonalization, depression, hopelessness, my life felt meaningless, I felt like I was dying and kept thinking about how I did not want to die!!! I felt doomed!!! I wanted to jump out of my skin and run out of the hospital!!!! I was about to rip the IV off my arm. Tremendous emotional despair and near-death experience!!! It was a nightmare while being awake!! I would much rather have the migraine!!!"

• MaK...
• Taken for less than 1 month
• February 8, 2021

Metoclopramide for Nausea/Vomiting "I was given Reglan via IV injection in the ER because of nausea. When I tell you this is the worst drug I've ever taken, I mean it. As soon as it was injected, I felt like I was in a different world. I then threw up 15 times, and it is almost a week after taking it, and I am just now getting over the suicidal thoughts and depression. I still have nightmares and anxiety, but nothing like it was. I will never take this drug again, and neither will my children when I have them because I think this drug shouldn't be on the market."

• Anonymous
• October 28, 2019

Metoclopramide for Gastroparesis "I am a female in my mid-20s. I was given Reglan for issues related to previous abdominal surgery and gastroparesis. I only took it for about 2 days before I stopped. I felt extremely restless and couldn't stop sleeping, but also was never comfortable enough to fully fall asleep. I also felt like I was in a psychotic episode that was never going to end. I was extremely irritated/agitated, very depressed, and having suicidal thoughts. I thought I needed to quit my job and couldn't have a conversation with anyone. I know my doctor had no way of knowing how I would react to Reglan, and some people do well, but I think this is way too risky to be handing out."

• Sis...
• Taken for less than 1 month
• July 29, 2019

Metoclopramide for Nausea/Vomiting "I was given medication through IV for a flare-up of vertigo. I am so glad I found this thread because it just confirms I wasn't crazy. I literally described these same feelings to my family after. It's been a week, and I don't feel myself still. So immediately after the injection, I felt like I wanted to run out of the hospital. I sat up in the bed and wanted to peel my face off. I felt sad, hopeless, and like if it didn't stop, I would go crazy. I got so worried I called my mom and told her my body is so agitated and I can't stop moving. If I called the doctor in, I wouldn't even be able to talk for him to understand because this felt HORRIBLE and like I was being tortured. Avoid this drug, please. These comments are real!"

• Sis...
• Taken for less than 1 month
• July 29, 2019

Metoclopramide for Nausea/Vomiting "I was given medication through IV for a flare-up of vertigo. I am so glad I found this thread because it just confirms I wasn't crazy. I literally described these same feelings to my family after. It's been a week, and I don't feel myself still. So immediately after the injection, I felt like I wanted to run out of the hospital. I sat up in the bed and wanted to peel my face off. I felt sad, hopeless, and like if it didn't stop, I would go crazy. I got so worried I called my mom and told her my body is so agitated and I can't stop moving. If I called the doctor in, I wouldn't even be able to talk for him to understand because this felt HORRIBLE and like I was being tortured. Avoid this drug, please. These comments are real!"

• Cha...
• Taken for less than 1 month
• October 25, 2020

Metoclopramide "Please do not take this drug, Reglan! I was given it in an IV for headaches, but this drug gave me the worst feeling I have ever had in my life! I thought I was going to die! Immediately, it gave me a hot feeling going through my body like when you take the dye before having an MRI scan. I felt dizzy, confused, depressed, and could not even think properly. I could not carry on a conversation! I could not feel my feet, and I had trouble moving my legs. I prayed for relief from these side effects! This drug is awful! There is no way I can describe how it made me feel! I honestly would not take it again for a billion dollars! Please do not give this drug to any patients and make sure you do not let anyone give it to you! This drug is horrific! About 10 hours later, I am okay now. And I thank God I made it through that horrible experience! Never again!!!!"

• Mar...
• Taken for less than 1 month
• August 25, 2022

Metoclopramide for Migraine "Never take this. This was given to me in the hospital for a migraine. I had a horrible anxiety attack and thought I was going to die. I have been severely depressed since then and have horrible anxiety. Anyone else feel this way?"

• Nev...
• November 12, 2009

Metoclopramide for Nausea/Vomiting "This was given to me as an IV, and I felt restless and anxious. I had hallucinations and unbelievable depression and emotional pain. I thought I went crazy and had suicidal thoughts. I was depressed for a month after that. I couldn't tell you if it worked because I was too busy arguing with myself on whether I was crazy. I am one of those people who never thought suicide was an answer to anything, but this medicine made me believe it was the only answer."

• Nev...
• November 12, 2009

Metoclopramide for Nausea/Vomiting "This was given to me as an IV, and I felt restless and anxious. I had hallucinations and unbelievable depression and emotional pain. I thought I went crazy and had suicidal thoughts. I was depressed for a month after that. I couldn't tell you if it worked because I was too busy arguing with myself on whether I was crazy. I am one of those people who never thought suicide was an answer to anything, but this medicine made me believe it was the only answer."

• lil...
• Taken for less than 1 month
• May 30, 2023

Metoclopramide for Migraine "Caused immediate dystonic reaction, hallucinations, derealization, depersonalization, agoraphobia, monophobia, daily panic attacks, severe depression, akathisia, legs stopped working, muscle tremors, severe fatigue, chills, fainting, diarrhea, nausea, dry heaving, loss of appetite, acid reflux, shortness of breath, red burning skin, numbness in limbs, headache, restlessness, chest pain. Was given this drug via IV one-time dose! It has now been 6 months and I am still completely disabled, feels like I'm living in a dream, scared all of the time, can't eat, no joy, suffering for months on end. I’ve heard it can take a year or more to recover. Please join the Reglan Support Group on Facebook if you are suffering long-term effects from this med and don’t let doctors gaslight you! Keep in mind I have no history of mental illness and now have similar issues to TBI and severe panic disorder."

• Anonymous
• January 3, 2012

Metoclopramide for Nausea/Vomiting "I have been taking this medicine off and on for about 2 years. When I first started, I hated it because it made me feel anxious, depressed, and emotional. I was on 10 mg a few times a day. It took the sickness away, but I couldn't handle the side effects, so I stopped, and the sickness came back. Finally, the doctor cut it down to 5 mg, and I felt so much better with that. The side effects were gone, and the sickness was controlled too. I'm doing very well with this medicine, but the long-term use still has me nervous because I don't want to develop tremors later. So far, so good, and I feel pretty good."

• Hfe...
• Taken for 1 to 6 months
• May 21, 2019

Metoclopramide for Lactation Augmentation "I was given Reglan off-label to promote the progesterone hormone to increase my breast milk supply after my son was born. After taking it steadily and gradually upping the dose after a couple of weeks, I started having severe side effects. I went in to work one morning and couldn’t remember how to do my job, I would fall asleep at traffic lights, had difficulty concentrating and focusing my eyes, and finally started having severe panic attacks, depression, and tardive dyskinesia. I ended up in the ER and had to get under psychiatric care. 14 years later, I still have to be on anxiety meds, and if I try to get off, the symptoms return. Be very careful taking this medicine."

• Nik...
• Taken for 1 to 6 months
• January 31, 2016

Metoclopramide for Lactation Augmentation "The purpose of my writing this review is to warn nursing mothers against using this drug. The drug worked - it increased my milk supply - but at a very high cost. Prior to taking Reglan, I had never had issues with depression or insomnia and very little issues with anxiety. Throughout the latter part of my taking this drug, anxiety increased steadily. Then I stopped sleeping. I became extremely anxious and severely depressed. After over two weeks going on a total of no more than 15 hours of sleep, I was admitted to the hospital. While in the hospital, I stopped taking Reglan. After five days off the drug, I was fine. Please do not take this drug. The other reviews are accurate as well. It is not worth it."

• mig...
• Taken for 1 to 6 months
• November 3, 2016

Metoclopramide for Migraine "If you have never taken this drug, don't! Reglan was given to me for my migraine. I have anxiety normally. Once given Reglan, I had panic attacks, jumping up, freaking out, trying to get the hell out of the hospital. They wouldn't let me leave, so I started ripping out my IV and started walking out. They caught me and strapped me down, which I fought. I cried, my body shook, impending dread, depression with an overactive panic attack. Forgo the Benadryl. It didn't help but said I was 'allergic to it,' so they gave me Benadryl, and they gave me 2 mg of Lorazepam, and I started to calm down. I wanted to die. Since then, I tell them I'm allergic to it, but I still have panic attacks every time I'm in the ER and severe anxiety. I need meds for it now."

• Ash...
• Taken for 1 to 6 months
• May 10, 2017

Metoclopramide for Nausea/Vomiting "I was given Reglan about two months ago to subside the vomiting that came along with hyperemesis gravidarum from my pregnancy. While it fixed that issue, it gave me the worst depression. I don't want to leave my bed, shower, or take care of myself or anything else. I'm letting go of this drug tomorrow."

• Joj...
• Taken for less than 1 month
• February 3, 2017

Metoclopramide for Lactation Augmentation "Took it while breastfeeding to help increase my milk production. While it worked for that, it also put me into a severe depression, which I had never experienced before. My family and doc were convinced I was suffering from PPD (just the phrase, 'How are you?' would send me sobbing). After doing a little research, I learned of the side effect and stopped taking it. The symptoms ceased almost immediately. About 2 weeks later, as my milk production slowed, I thought I'd give it another try (thinking I'd be able to combat the feelings, now that I knew the cause). Within a few hours, I could literally feel the black cloud of depression descend. It was terrifying. I never took another pill and have never had another bout of depression."

• Dan...
• August 19, 2020

For GERD "I was prescribed metoclopramide on the 13th of this month for bad GERD I have been having for a while! My primary care doctor prescribed this medication to me. Normally, before I take medication, I read up on the side effects, this time I didn’t do that. I took it as soon as I got home, and I had to go somewhere soon after. I tried to drive, made it on the expressway, and got to a red light, and all hell broke loose. I started sweating, hyperventilating, couldn’t breathe, lost all my breath, felt like someone punched me, I got weak, I felt sad, doomed! I thought it was the end of my life. On the ride, I had to pull over somewhere while traffic was coming. I was instantly confused! I managed to pull over and have my parents come and get me. My mom had to drive my car back home! Now it’s the 18th. I’ve given it some time to wear off, doctors can’t tell me what to take for the symptoms to wear off! They are no help! Do not take!"

• Jos...
• Taken for less than 1 month
• August 22, 2021

Metoclopramide for GERD "Side effects experienced with Reglan: Reglan made me suicidal, depressed, almost took my life!!! Was scared to death. I developed akathisia, suicidal thoughts, my brain was talking to me telling me to take me and my dog's life, and this is NOT me! My parents had to watch me every day until I had to be placed on an antidepressant and had to wait 6-7 weeks until it kicked in! I’ll never be the same! 1 year later, I'm still on an antidepressant with so many up and down days, still completely depersonalized! So many times I wanted to give up, but I prayed every night to keep pushing and saying to myself my future will be so bright. Couldn’t eat, sleep, or even bathe myself, my family had to take care of me! With just ONE DOSE! This pill is so strong! To do something like this to me, I’ve never ever!!! Out of all the meds I had to be placed on and tried for my stomach condition, never experienced ANYTHING like this! It may work for some people."

• hai...
• Taken for less than 1 month
• April 7, 2019

Metoclopramide "DO NOT take this medicine. May be the worst drag I ever taken. I have a lot of side effects, like depression, and my face numb, my neck stiff like stone, my body shake for 9 days now, and I only took it for 3 days at a dose of 3 times a day."

• SMJ...
• Taken for less than 1 month
• March 1, 2016

For Migraine "About 2 weeks ago, I had a migraine that lasted for about 3 days until I finally went to the ER. When I was seen, the doctor gave me a mix of Reglan and Benadryl in an IV, and boy, was that the biggest mistake of my life. At first, I felt silly and sleepy and even laughed a little. Then the next thing I know, my eyes are wide because my heart starts racing like crazy! I already suffer from anxiety, I wish she would have mentioned the side effects before she injected me with the meds. I would have never taken it via IV. I thought I was gonna die! I called the doctor back in and she told me to just calm down. My heart rate finally calmed, but then I started shaking. Then came sleep. I woke up and felt a little better. It made me feel depressed a few days later. Traumatized forever."

• Ell...
• Taken for 1 to 6 months
• February 1, 2021

For GERD "I was prescribed this drug, metoclopramide, for persistent GERD/functional dyspepsia symptoms. It worked beautifully within a matter of days. I was taking it 3 times a day. I started feeling a little anxious a week or two after starting this drug, but I didn’t put two and two together. I was on it for 6 weeks, 4 of which were plagued with anxiety and not feeling like myself at all. After doing some research, I realized it could be a side effect from the drug. I quit cold turkey on Jan. 1, 2021, and had horrible depression for 2 days, followed by anxiety for 2 weeks. I thought it would never go away after reading some other reviews online. I’m happy to say the side effects do go away and to hang in there. This drug does wonderful things for some people but causes debilitating side effects for others. I recommend trying something different. And if you’re in the middle of an anxiety or depression spiral since coming off of this drug, please trust that it gets better."

• Zel...
• Taken for less than 1 month
• September 13, 2016

Metoclopramide for GERD "I was prescribed this medicine for GERD. I had not been able to eat or drink anything for a couple of days, so I was feeling pretty terrible anyway. After I started to take this medicine, I became extremely depressed and anxious. I could not stay awake for more than 20 minutes at a time, and that entire time I was so nauseous I didn't want to be awake. I had terrible back pain, and I was shaking like I had been out in the Arctic. Finally, my dad told me not to take the Reglan and to see what happened. I skipped my 10 P.M. dose and woke up about 10 A.M. the next day. I felt completely fine, other than my back was still sore. I lost three days of my life to this drug, and I can't believe a medicine that is supposed to help you can do so much harm."

• Sia...
• Taken for 1 to 6 months
• July 11, 2019

For Nausea/Vomiting "While metoclopramide does help a lot with nausea and vomiting, the trade-off is fatigue and even depression. If you let the bad outweigh the good, this isn't for you. But if you can handle the fatigue and depression, then this works out when you really need it."

• Lea...
• Taken for less than 1 month
• July 1, 2017

For Nausea/Vomiting "Wow, there are a lot of negative reviews about this drug... and yes, every drug affects everyone differently. But I was reading how people got anxiety and horrible depression from it. For me, I never got that, but I'm already on antidepressant and anti-anxiety medication, so that could be it... I never got any side effects from it. It worked AMAZINGLY for vomiting and feeling nauseous... it was the only thing that worked for me!! I do give it 10/10 for sure. :)"