Comparing Flexeril vs Zanaflex
| Flexeril (cyclobenzaprine) | Zanaflex (tizanidine) |
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| Flexeril (cyclobenzaprine) | Zanaflex (tizanidine) |
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Prescription only
Flexeril is a muscle relaxant that may be used short-term in addition to rest and physical therapy to treat muscle spasms caused by musculoskeletal conditions. Sedation is a common side effect... View more |
Prescription only
Prescribed for Muscle Spasm, Spasticity. Zanaflex may also be used for purposes not listed in this medication guide. |
Related suggestions Muscle Spasm (Involuntary Hypertonicity)
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| More about Flexeril (cyclobenzaprine) | More about Zanaflex (tizanidine) | ||||||||
| Ratings & Reviews | |||||||||
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Flexeril has an average rating of 6.1 out of 10 from a total of 238 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 26% reported a negative effect. |
Zanaflex has an average rating of 7.6 out of 10 from a total of 116 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 12% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Flexeril side effects |
View all Zanaflex side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zanaflex prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
| Other cyclobenzaprine brands include: Amrix, Comfort Pac with Cyclobenzaprine | Other tizanidine brands include: Ontralfy | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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72 hours |
2.5 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 452 drugs are known to interact with Flexeril:
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A total of 652 drugs are known to interact with Zanaflex:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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August 26, 1977 |
November 27, 1996 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.