Comparing Ethosuximide vs Zonisamide

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ethosuximide	Zonisamide	Enter another drug to compare

Ethosuximide

Zonisamide

Prescription only

Prescribed for Epilepsy, Seizures. Ethosuximide may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Migraine Prevention, Benign Essential Tremor, Seizures, Parkinsonian Tremor, Epilepsy. Zonisamide may also be used for purposes not listed in this medication guide.

More about Ethosuximide

More about Zonisamide

Ratings & Reviews

Ethosuximide has an average rating of 7.7 out of 10 from a total of 12 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 17% reported a negative effect.

Zonisamide has an average rating of 5.6 out of 10 from a total of 146 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 37% reported a negative effect.

View all 12 reviews

View all 146 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Ethosuximide side effects

Memory loss (13.0%)
Depression (11.6%)
Loss of appetite (9.6%)
Weight loss (9.6%)
Headaches (8.9%)
Anger (6.8%)
Anxiety (6.8%)

View all Zonisamide side effects

Drug Class

Succinimide anticonvulsants

Carbonic anhydrase inhibitor anticonvulsants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 capsule
Strength	250 mg
Per unit^*	$0.38
Cost^*	$37.71

View all Ethosuximide prices

Quantity	100 each
Strength	100 mg
Per unit^*	$0.26
Cost^*	$25.60

View all Zonisamide prices

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Dosage Forms

Oral capsule
Oral syrup

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

60 hours

63 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 380 drugs are known to interact with Ethosuximide:

6 major drug interactions (21 brand and generic names)
364 moderate drug interactions (1980 brand and generic names)
10 minor drug interactions (39 brand and generic names)

A total of 413 drugs are known to interact with Zonisamide:

101 major drug interactions (588 brand and generic names)
307 moderate drug interactions (1120 brand and generic names)
5 minor drug interactions (11 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of ethosuximide such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of zonisamide such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

November 02, 1960

March 27, 2000

WADA Class View classifications

N/A

More Information

Patient Resources

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Ethosuximide vs Zonisamide

See also:

Lamictal

Carbamazepine

Levetiracetam

Lyrica

Topiramate

Diazepam

Lorazepam

Pregabalin

Lamotrigine

Clonazepam

Further information

Comparing Ethosuximide vs Zonisamide

See also:

Further information

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