Comparing Estradiol vs Estradiol Topical

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Estradiol

Estradiol topical

Prescription only

Estradiol is a synthetic form of estrogen that may be given for several different indications, including the relief of menopausal symptoms or low estrogen levels caused by other conditions. Its use... View more

Prescription only

Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Overactive Bladder, Dyspareunia. Estradiol topical may also be used for purposes not listed in this medication guide.

More about Estradiol

More about Estradiol topical

Ratings & Reviews

Estradiol has an average rating of 5.8 out of 10 from a total of 592 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 37% reported a negative effect.

Estradiol topical has an average rating of 5.1 out of 10 from a total of 490 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 45% reported a negative effect.

View all 592 reviews

View all 490 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Hot flashes (17.4%)
Itching (7.1%)
Night sweats (6.1%)
Headaches (5.4%)
Insomnia (5.2%)
Mood swings (4.2%)
Rash (4.1%)

View all Estradiol side effects

Burning (13.5%)
Headaches (6.7%)
Itching (6.7%)
Pain (6.5%)
Dryness (5.3%)
Cramps (4.5%)
Hair loss (4.5%)

View all Estradiol topical side effects

Drug Class

Estrogens

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	1 mg
Per unit^*	$0.54
Cost^*	$16.14

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Quantity	42.5 gram(s)
Strength	0.1 mg/g
Per unit^*	$0.89
Cost^*	$37.76

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Dosage Forms

Intramuscular solution
Oral tablet
Transdermal gel

Vaginal cream
Vaginal insert

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 390 drugs are known to interact with Estradiol:

34 major drug interactions (84 brand and generic names)
336 moderate drug interactions (1248 brand and generic names)
20 minor drug interactions (98 brand and generic names)

A total of 258 drugs are known to interact with Estradiol topical:

33 major drug interactions (82 brand and generic names)
209 moderate drug interactions (777 brand and generic names)
16 minor drug interactions (60 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

July 23, 1975

January 31, 1984

WADA Class View classifications

N/A

More Information

Patient Resources

Estradiol uses

Estradiol topical uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Estradiol vs Estradiol Topical

See also:

Premarin

Estrace

Botox

Estradiol Patch

Vagifem

Yuvafem

Estrace Vaginal Cream

Prempro

Dotti

Conjugated estrogens

Further information

Comparing Estradiol vs Estradiol Topical

See also:

Further information

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