Comparing Dapagliflozin vs Metformin

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Dapagliflozin	Metformin	Enter another drug to compare

Dapagliflozin

Metformin

Prescription only

Prescribed for Heart Failure, Chronic Kidney Disease, Type 2 Diabetes. Dapagliflozin may also be used for purposes not listed in this medication guide.

Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

More about Dapagliflozin

More about Metformin

Ratings & Reviews

Dapagliflozin has an average rating of 4.7 out of 10 from a total of 197 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 46% reported a negative effect.

Metformin has an average rating of 6.8 out of 10 from a total of 656 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 197 reviews

View all 656 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Yeast infection (21.8%)
Frequent urination (10.7%)
Hair loss (9.1%)
Headaches (7.6%)
Dizziness (7.1%)
Urinary tract infection (7.1%)
Dehydration (6.6%)

View all Dapagliflozin side effects

Diarrhea (25.6%)
Nausea (15.4%)
Upset stomach (9.8%)
Stomach pain (4.7%)
Gas (4.6%)
Headaches (4.4%)
Cramps (3.7%)

View all Metformin side effects

Drug Class

SGLT-2 inhibitors

Non-sulfonylureas

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	5 mg
Per unit^*	$15.82
Cost^*	$474.63

View all Dapagliflozin prices

Quantity	100 each
Strength	500 mg
Per unit^*	$0.15 - $0.24
Cost^*	$15.37 - $24.08

View all Metformin prices

Get free Discount Card

Dosage Forms

Oral tablet

Oral solution
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12.9 hours

4.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 373 drugs are known to interact with Dapagliflozin:

2 major drug interactions (10 brand and generic names)
365 moderate drug interactions (1797 brand and generic names)
6 minor drug interactions (23 brand and generic names)

A total of 377 drugs are known to interact with Metformin:

24 major drug interactions (129 brand and generic names)
344 moderate drug interactions (1798 brand and generic names)
9 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Disease Interactions

First Approval Date

January 08, 2014

March 03, 1995

WADA Class View classifications

N/A

More Information

Patient Resources

Dapagliflozin uses

Metformin uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Dapagliflozin vs Metformin

See also:

Trulicity

Lantus

Ozempic

Tresiba

Victoza

Levemir

Basaglar

Novolog

Toujeo SoloStar

Soliqua

Further information

Comparing Dapagliflozin vs Metformin

See also:

Further information

Compare Drugs