Comparing Cymbalta vs Spravato
| Cymbalta (duloxetine) | Spravato (esketamine) |
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| Cymbalta (duloxetine) | Spravato (esketamine) |
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Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Prescription only
Prescribed for Major Depressive Disorder, Depression. Spravato may also be used for purposes not listed in this medication guide. |
Related suggestions Depression
Major Depressive Disorder
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| More about Cymbalta (duloxetine) | More about Spravato (esketamine) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Cymbalta has an average rating of 6.3 out of 10 from a total of 1904 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
Spravato has an average rating of 6.3 out of 10 from a total of 125 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Cymbalta side effects |
View all Spravato side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Cymbalta prices |
View all Spravato prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other duloxetine brands include: Drizalma Sprinkle, Irenka |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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17 hours |
12 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 633 drugs are known to interact with Cymbalta:
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A total of 296 drugs are known to interact with Spravato:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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N/A |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.