Bupropion / naltrexone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion / naltrexone	Wegovy (semaglutide)	Phentermine	Enter another drug to compare

Bupropion / naltrexone

Wegovy (semaglutide)

Phentermine

Prescription only

Prescribed for Weight Loss (Obesity/Overweight). Bupropion / naltrexone may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction. Wegovy may also be used for purposes not listed in this medication guide.

Prescription only

Phentermine may be used short-term as an aid to weight loss; however, it can be addictive and tolerance may develop to its weight-losing effects, rendering it less effective with time. Prescribed for... View more

More about Bupropion / naltrexone

More about Wegovy (semaglutide)

More about Phentermine

Ratings & Reviews

Bupropion / naltrexone has an average rating of 6.6 out of 10 from a total of 2076 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Wegovy has an average rating of 7.6 out of 10 from a total of 516 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 14% reported a negative effect.

Phentermine has an average rating of 8.6 out of 10 from a total of 3015 ratings on Drugs.com. 82% of reviewers reported a positive effect, while 5% reported a negative effect.

View all 2076 reviews

View all 516 reviews

View all 3015 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (32.3%)
Headaches (17.5%)
Constipation (12.0%)
Dizziness (11.2%)
Dry mouth (9.0%)
Tiredness (5.8%)
Anxiety (5.3%)

View all Bupropion / naltrexone side effects

Nausea (32.6%)
Constipation (14.9%)
Vomiting (10.5%)
Diarrhea (9.9%)
Headaches (7.0%)
Tiredness (6.6%)
Heartburn (6.4%)

View all Wegovy side effects

Dry mouth (26.7%)
Insomnia (9.8%)
Headaches (6.9%)
Anxiety (6.4%)
Constipation (4.5%)
Increased heart rate (3.6%)
Loss of appetite (3.0%)

View all Phentermine side effects

Drug Class

Anorexiants

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

N/A

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	7 tablet
Strength	37.5 mg
Per unit^*	$0.84
Cost^*	$5.90

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Dosage Forms

N/A

Subcutaneous solution

Oral capsule
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

21 hours

168 hours

20 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 781 drugs are known to interact with Bupropion / naltrexone:

220 major drug interactions (957 brand and generic names)
556 moderate drug interactions (2589 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 275 drugs are known to interact with Wegovy:

16 major drug interactions (36 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 196 drugs are known to interact with Phentermine:

43 major drug interactions (184 brand and generic names)
151 moderate drug interactions (744 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Using phentermine with alcohol can increase the risk of cardiovascular side effects such as... View more

Disease Interactions

First Approval Date

September 10, 2014

N/A

August 14, 1973

WADA Class View classifications

N/A

S6 - Stimulants

More Information

Patient Resources

Wegovy uses

Phentermine uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Bupropion / naltrexone Alternatives Compared

See also:

Ozempic

Mounjaro

Wegovy

Rybelsus

Zepbound

Victoza

Saxenda

Alli

Tirzepatide

Phentermine

Further information

Bupropion / naltrexone Alternatives Compared

See also:

Further information

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