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Bupropion / naltrexone Side Effects

In Summary

Commonly reported side effects of bupropion/naltrexone include: constipation, dizziness, headache, insomnia, nausea, and vomiting. Other side effects include: anxiety, diarrhea, increased blood pressure, tremor, depression, hypertension, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bupropion / naltrexone: oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by bupropion / naltrexone. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking bupropion / naltrexone:

More common:
  • Blurred vision
  • discouragement
  • dizziness
  • fear or nervousness
  • feeling sad or empty
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • pounding in the ears
  • slow or fast heartbeat
  • tiredness
  • trouble concentrating
  • trouble sleeping
Less common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain
  • shakiness in the legs, arms, hands, or feet
  • trembling or shaking of the hands or feet
Less common or rare:
  • Chest pain or discomfort
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • vomiting
Rare
  • Changes in behavior
  • thoughts of killing oneself
Incidence not known:
  • Abdominal or stomach pain or tenderness
  • aggressive or angry
  • anxiety
  • blistering, peeling, or loosening of the skin
  • chills
  • clay colored stools
  • cough
  • dark urine
  • decreased appetite
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • diarrhea
  • difficulty with moving
  • difficulty with swallowing
  • dry mouth
  • false beliefs that cannot be changed by facts
  • feeling that others are watching you or controlling your behavior
  • feeling, seeing, or hearing things that are not there
  • fever
  • hives, itching, or rash
  • hyperventilation
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • muscle stiffness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • restlessness
  • severe mood or mental changes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the feet or lower legs
  • tightness in the chest
  • unusual behavior unusual tiredness or weakness yellow eyes or skin

If any of the following symptoms of overdose occur while taking bupropion / naltrexone, get emergency help immediately:

Symptoms of overdose:
  • Blue lips, fingernails, or skin
  • change in consciousness
  • confusion
  • decreased awareness or responsiveness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • loss of consciousness
  • muscle cramps or spasms
  • severe sleepiness
  • sweating

Minor Side Effects

Some of the side effects that can occur with bupropion / naltrexone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • difficulty having a bowel movement (stool)
Less common:
  • Abdominal or stomach pain
  • change or loss of taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • feeling of warmth
  • hearing loss
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
Less common or rare:
  • Dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • hair loss
  • indigestion
  • sensation of spinning
  • severe nausea or vomiting
  • thinning of the hair

For Healthcare Professionals

Applies to bupropion / naltrexone: oral tablet extended release

Psychiatric

Very common (10% or more): Sleep disorders (up to 13.8%)
Common (1% to 10%): Depression, anxiety, irritability
Uncommon (0.1% to 1%): Insomnia, abnormal dreams, nervousness, dissociation (feeling spacey), tension, agitation, mood swings
Rare (less than 0.1%): Suicidal ideation[Ref]

Nervous system

Very common (10% or more): Headache (up to 17.6%), dizziness (up to 10.4%)
Common (1% to 10%): Tremor, dysgeusia, attention disorders
Uncommon (0.1% to 1%): Vertigo, motion sickness, disturbance in attention, lethargy, intention tremor, balance disorder, memory impairment, amnesia, mental impairment, presyncope/syncope, hernia, seizure[Ref]

Cardiovascular

Common (1% to 10%): Hot flush, hypertension, increased blood pressure, palpitations
Uncommon (0.1% to 1%): Tachycardia, myocardial infarction
Frequency not reported: Increased heart rate[Ref]

Hepatic

Uncommon (0.1% to 1%): Cholecystitis, increased hepatic enzymes[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, rash
Uncommon (0.1% to 1%): Alopecia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 32.5%), constipation (up to 19.2%), vomiting (up to 10.7%)
Common (1% to 10%): Dry mouth, diarrhea, upper abdominal pain, viral gastroenteritis, abdominal pain
Uncommon (0.1% to 1%): Lower abdominal pain, eructation, lip swelling, hematochezia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Vaginal hemorrhage, irregular menstruation, erectile dysfunction, vulvovaginal dryness[Ref]

Hematologic

Uncommon (0.1% to 1%): Decreased hematocrit[Ref]

Immunologic

Common (1% to 10%): Influenza[Ref]

Metabolic

Uncommon (0.1% to 1%): Dehydration[Ref]

Musculoskeletal

Common (1% to 10%): Muscle strain
Uncommon (0.1% to 1%): Intervertebral disc protrusion, jaw pain[Ref]

Other

Common (1% to 10%): Fatigue, tinnitus
Uncommon (0.1% to 1%): Feeling jittery, feeling abnormal, asthenia, thirst, feeling hot, staphylococcal infection[Ref]

Renal

Uncommon (0.1% to 1%): Kidney infection, increased blood creatinine, increased serum creatinine, micturition urgency[Ref]

Respiratory

Uncommon (0.1% to 1%): Pneumonia[Ref]

References

1. "Product Information. Contrave (buPROPion-naltrexone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Not all side effects for bupropion / naltrexone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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