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Bupropion / Naltrexone Dosage

Medically reviewed by Drugs.com. Last updated on Mar 22, 2023.

Applies to the following strengths: 90 mg-8 mg

Usual Adult Dose for Weight Loss

Each extended-release tablet contains naltrexone 8 mg/bupropion 90 mg:

Initial dose:

Maintenance dose: 2 tablets orally 2 times a day (morning and evening)
Maximum dose: 4 tablets/day (naltrexone 32 mg/bupropion 360 mg)

Comments:

Uses: As an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).

Renal Dose Adjustments

Mild renal impairment: No adjustment recommended
Moderate renal impairment: Maximum dose: 1 tablet orally 2 times a day (morning and evening)
Severe renal impairment: Maximum dose: 1 tablet orally 2 times a day (morning and evening)
ESRD: Not recommended

Liver Dose Adjustments

Mild hepatic impairment: No adjustment recommended
Moderate hepatic impairment: Maximum dose: 1 tablet orally 2 times a day (morning and evening)
Severe hepatic impairment: Not recommended

Dose Adjustments

Elderly: Use caution; elderly patients are more likely to have impaired renal function, therefore, consider monitoring renal function

Concomitant Use of MAOIs: Contraindicated


Concomitant Use with CYP450 2B6 Inhibitors:

Avoid Concomitant Use with CYP450 2B6 Inducers

Precautions

US BOXED WARNING: SUICIDAL THOUGHTS AND BEHAVIORS


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD: Not recommended

Other Comments

Administration advice:


Missed dose: If a dose is missed, do not take an additional dose, but take the prescribed next dose at the usual time

General:

Monitoring:

Patient Advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.