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Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Benadryl Vicks NyQuil Cold & Flu Nighttime Relief
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Benadryl (diphenhydramine) Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Prescription and OTC

Prescribed for Cold Symptoms, Influenza. acetaminophen / dextromethorphan / guaifenesin / phenylephrine may also be used for purposes not listed in this medication guide.

Prescription and OTC

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more

Over-the-counter

Prescribed for Cough, Cold Symptoms. Vicks NyQuil Cold & Flu Nighttime Relief may also be used for purposes not listed in this medication guide.

More about Acetaminophen / dextromethorphan / guaifenesin / phenylephrine More about Benadryl (diphenhydramine) More about Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Ratings & Reviews

Acetaminophen / dextromethorphan / guaifenesin / phenylephrine has an average rating of 7.3 out of 10 from a total of 4 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 25% reported a negative effect.

Benadryl has an average rating of 7.2 out of 10 from a total of 77 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect.

Vicks NyQuil Cold & Flu Nighttime Relief has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect.

View all 4 reviews

View all 77 reviews

View all 1 reviews

Drug Class
Side Effects

See also: acetaminophen / dextromethorphan / guaifenesin / phenylephrine side effects in more detail.

See also: Benadryl side effects in more detail.

See also: Vicks NyQuil Cold & Flu Nighttime Relief side effects in more detail.
Generic Availability

Lower cost generic

N/A

N/A
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 24 tablet
Dosage 25 mg
Per Unit* $0.42
Cost* $9.99

View all Benadryl prices

We could not find an exact match for this medicine. Try searching the Price Guide directly.

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Dosage Forms Available
  • Oral liquid
  • Oral tablet
  • Oral capsule
  • Oral tablet

N/A
Brand Names
Adult Cold, Flu & Sore Throat, Alka-Seltzer Plus Day Severe Cold+Flu Hot Drink Mix, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Alka-Seltzer Plus Severe Cough, Mucus & Congestion Liquid Gels, Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels, Cold & Cough PE Multi-Symptom, Cold Head Congestion, Cold Multi-Symptom Severe, ConRx Cold, Cough & Cold Relief, CounterAct Day, Decorel Forte Plus, Delsym Cough+ Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Children's FreeFrom Multi-Symptom Cold, Flu & Sore Throat, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Cold, Flu & Sore Throat Liquid Gels, Mucinex Fast-Max Day Time Severe Cold, Mucinex Fast-Max Severe Cold, Mucinex Fast-Max Severe Congestion & Cold, Mucinex Sinus-Max Pressure, Pain & Cough, Mucus Relief Complete, Mucus Relief Plus, Robitussin Severe Multi-Symptom Cough Cold + Flu, Rompe Pecho MAX, Sudafed PE Cold & Cough, Sudafed PE Head Congestion + Flu Severe, Sudafed PE Pressure+Pain+Cold, Suphedrine PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold + Mucus Severe, Tylenol Cold Multi-Symptom Severe, Tylenol Cough & Severe Congestion Daytime, Vicks DayQuil Severe Cold & Flu View more Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Other acetaminophen / dextromethorphan / doxylamine brands include: Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Clear Cough PM Multi-Symptom, Contac Cold + Flu (Night) Cooling Relief Liquid, Coricidin HBP Nighttime Multi-Symptom Cold, Delsym Night Time Cough & Cold, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime, Tylenol Cough & Sore Throat Nightime, Vicks Nature Fusion Cold & Flu Nighttime Relief, Vicks NyQuil HBP Cold & Flu View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

N/A

9.3 hours

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CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
N
Category N Not classified
Drug Interactions

A total of 588 drugs are known to interact with acetaminophen / dextromethorphan / guaifenesin / phenylephrine:

  • 92 major drug interactions (282 brand and generic names)
  • 479 moderate drug interactions (2012 brand and generic names)
  • 17 minor drug interactions (60 brand and generic names)

A total of 448 drugs are known to interact with Benadryl:

  • 14 major drug interactions (90 brand and generic names)
  • 432 moderate drug interactions (1671 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 492 drugs are known to interact with Vicks NyQuil Cold & Flu Nighttime Relief:

  • 90 major drug interactions (328 brand and generic names)
  • 386 moderate drug interactions (1548 brand and generic names)
  • 16 minor drug interactions (55 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness... View more
Disease Interactions
First Approval Date

N/A

March 04, 1946

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

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N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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