Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Jul 9, 2025.

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Adult Dose for Influenza

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Influenza

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:

• Current use of any other drug containing acetaminophen.
• Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
• Hypersensitivity to any of the ingredients

Safety and efficacy have not been established in patients younger than 6 years.

Dialysis

Data not available

Other Comments

Administration advice:

• Use only provided measuring cups for liquid formulations.
• Do not crush or chew tablets or softgels.

Patient advice:

• Take only as directed.
• This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
• Do not use with any other drug containing acetaminophen.
• Avoid drinking alcohol while on this drug.
• If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
• Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer