Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine Dosage
Medically reviewed by Drugs.com. Last updated on Dec 1, 2021.
Applies to the following strengths: 325 mg-10 mg-200 mg-5 mg; 325 mg-10 mg-200 mg-5 mg/15 mL; 325 mg-10 mg-100 mg-5 mg; 325 mg-15 mg-200 mg-5 mg; 650 mg-20 mg-400 mg-10 mg/20 mL; 500 mg-20 mg-400 mg-10 mg; 325 mg-10 mg-200 mg-5 mg/10 mL; 650 mg-20 mg-400 mg-10 mg
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Usual Adult Dose for Influenza
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Usual Pediatric Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Usual Pediatric Dose for Influenza
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution.
Precautions
CONTRAINDICATIONS:
-Current use of any other drug containing acetaminophen.
-Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
-Hypersensitivity to any of the ingredients
Safety and efficacy have not been established in patients younger than 6 years.
Dialysis
Data not available
Other Comments
Administration advice:
-Use only provided measuring cups for liquid formulations.
-Do not crush or chew tablets or softgels.
Patient advice:
-Take only as directed.
-This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
-Do not use with any other drug containing acetaminophen.
-Avoid drinking alcohol while on this drug.
-If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
-Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.
More about acetaminophen / dextromethorphan / guaifenesin / phenylephrine
- Side Effects
- During Pregnancy
- Drug Images
- Drug Interactions
- En Español
- 2 Reviews
- Drug class: upper respiratory combinations
Patient resources
- Drug Information
- Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Caps & Tabs
- Acetaminophen, Dextromethorphan, Guaifenesin, and Phenylephrine Liquid
- Other brands
- Vicks DayQuil Severe Cold & Flu, Tylenol Cold & Flu Severe, Sudafed PE Cold & Cough, Mucinex Fast-Max Severe Cold, ... +6 more
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.