Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Sep 7, 2023.

Applies to the following strengths: 325 mg-10 mg-200 mg-5 mg; 325 mg-10 mg-200 mg-5 mg/15 mL; 650 mg-20 mg-400 mg-10 mg/20 mL; 325 mg-10 mg-100 mg-5 mg; 500 mg-20 mg-400 mg-10 mg; 325 mg-15 mg-200 mg-5 mg; 325 mg-10 mg-200 mg-5 mg/10 mL; 650 mg-20 mg-400 mg-10 mg; 162.5 mg-5 mg-100 mg-2.5 mg

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Adult Dose for Influenza

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Influenza

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:

Current use of any other drug containing acetaminophen.
Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
Hypersensitivity to any of the ingredients

Safety and efficacy have not been established in patients younger than 6 years.

Dialysis

Data not available

Other Comments

Administration advice:

Use only provided measuring cups for liquid formulations.
Do not crush or chew tablets or softgels.

Patient advice:

Take only as directed.
This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
Do not use with any other drug containing acetaminophen.
Avoid drinking alcohol while on this drug.
If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.