Acetaminophen/dextromethorphan/guaifenesin/phenylephrine Interactions
There are 623 drugs known to interact with acetaminophen/dextromethorphan/guaifenesin/phenylephrine, along with 7 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 95 are major, 511 are moderate, and 17 are minor.
- View all 623 medications that may interact with acetaminophen/dextromethorphan/guaifenesin/phenylephrine
- View acetaminophen/dextromethorphan/guaifenesin/phenylephrine alcohol/food interactions (1)
- View acetaminophen/dextromethorphan/guaifenesin/phenylephrine disease interactions (7)
Most frequently checked interactions
View interaction reports for acetaminophen / dextromethorphan / guaifenesin / phenylephrine and the medicines listed below.
- 5-HTP (5-hydroxytryptophan)
- Adderall (amphetamine / dextroamphetamine)
- Advil PM (diphenhydramine / ibuprofen)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aleve (naproxen)
- Allegra (fexofenadine)
- Bactrim (sulfamethoxazole / trimethoprim)
- Benadryl (diphenhydramine)
- Cipro (ciprofloxacin)
- Cymbalta (duloxetine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- MethylPREDNISolone Dose Pack (methylprednisolone)
- Midol Complete (acetaminophen / caffeine / pyrilamine)
- Motrin (ibuprofen)
- Pepto-Bismol (bismuth subsalicylate)
- Prilosec (omeprazole)
- ProAir HFA (albuterol)
- Promethazine DM (dextromethorphan / promethazine)
- Sudafed PE Congestion (phenylephrine)
- Tramadol Hydrochloride ER (tramadol)
- Tussin (guaifenesin)
- Tylenol (acetaminophen)
- Vicks Dayquil Cold & Flu Relief (acetaminophen / dextromethorphan / phenylephrine)
- Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
- Vicks NyQuil Severe Cold & Flu (acetaminophen / dextromethorphan / doxylamine / phenylephrine)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Zinc (zinc sulfate)
- Zyrtec (cetirizine)
Acetaminophen/dextromethorphan/guaifenesin/phenylephrine alcohol/food interactions
There is 1 alcohol/food interaction with acetaminophen / dextromethorphan / guaifenesin / phenylephrine.
Acetaminophen/dextromethorphan/guaifenesin/phenylephrine disease interactions
There are 7 disease interactions with acetaminophen / dextromethorphan / guaifenesin / phenylephrine which include:
Report options
More about acetaminophen / dextromethorphan / guaifenesin / phenylephrine
- acetaminophen/dextromethorphan/guaifenesin/phenylephrine consumer information
- Compare alternatives
- Reviews (4)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
