User Reviews for Zonisamide
Also known as: Zonegran
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Zonisamide.
Reviews for Zonisamide to treat Migraine Prevention
"I've had migraine since I was 11. No preventative had ever worked. We do control the a symptomatic inter cranial pressure with acetazamide 250 mg 2/day. Recently my imatrix started causing rebounds and my monthly migraine totals shot up from 6-8 shot worthy (where the migraine causes a dark spot in the white matter in my brain) /month to 15-20 and I am living off of excedrine migraine. Neuro put me on this to be preventative. I've noticed little to no difference and am finding I'm gaining weight and am fighting depression and hopelessness when I'm alone. Neuro wants to up dosage to 400 mg /day but I don't think I can handle that. On a side note in order to try to get off meds in going to look into the implants because I can't maintain this"
Jenn C (taken for 1 to 6 months) August 10, 2016
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Zonegran (zonisamide): "I took 300mg of zonegran for nearly 2 years. It worked really well to prevent my migraines at the start--it was like a dream come true. I did experience appetite reduction and weight loss, but I put it back on after about a year. The negative side effects were extreme for me over time. First, my depression got much worse. That could have been external factors, but the time that I started taking Zonegran and the severe increase in my symptoms match. Also, after some time, I noticed my cognitive function was severely inhibited. I was in graduate school at the time and began failing classes, slurring my words when 100% sober, and unable to remember things. When I went off, my migraines returned severely, especially period and allergy migraines"
BLove01 March 18, 2016
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"Have suffered with headache/migraines for 22 years and have tried many meds. Tried Topamax a couple different times and finally had to get off it for some of the side effects and it really kinda stopped working for me. On dose 200 mg of Zonisamide and seems to have decreased the frequency and the severity of my migraines. Have noticed a bit of a loss of appetite at this current dose and thirsty and dry mouth. All in all happy so far with my current situation."
Alohawally (taken for less than 1 month) March 10, 2016
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"I started having daily migraines Sept. 2014. Topiramax (can't spell anymore). from primary MD. No improvement. Saw neurologist Dec. 2014. started on Zonisamide. 50mg. built up to 150mg. was having about 28 migraines pre meds. Decreased to about 22. for a few months. Then decreased to 14-18 per mo. summer of 2015. Took Pt. end of summer and headaches increased to upper 20s again. MRI done in summer showed Spinal Stenosis but no severe enough to warrant surgery. Dosage of Zonisamide increased to 250 mg. did not help so Neuro. decreased it back to 150mg. pain became more severe and every day. At present am on 200 mg. and to go up to 250 mg. next week. Still with migraines every day. Getting 2nd set of spinal injections with steroids tomorrow."
sissie67 February 17, 2016
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Zonegran (zonisamide): "I was taking 6-8 Excedrine Migraine daily to control my headaches. I saw a neurologist and was put on Zonegram. It took 1 month to build up to 100 mg per day. I was headache free after 2 months and have been that way for 3 months now. I will step down from the pills in 6 months. No side affects for me at all ."
James_D (taken for 1 to 6 months) January 5, 2016
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"My migraines started suddenly at age 52 have no idea why. I have tried several different medicine including topomax I am now taking 400 mg zanisamide as first preventive and starting another new medicine this next week to see if it will help the head pain. I get daily migraines scale 3 -5 on a average and can increase at anytime through the day to 6-7 at which time I have to take a treximet or wait to see if it passes, sleep, ice quite what ever I can do till it goes away. I have also tried botox that didn't work either"
Bluwillow September 26, 2015
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"I am up to 200mg a day. The only problems I have is, some loss of appetite; which I definitely don't mind. And I get a little upset tummy every now and then. All in I feel fine, my memory is fine, & I'm just glad I can live a normal life pain free! My last migraine was during my dosage increase @ 175mg. Hopefully its smooth sailing from here."
msqui45 (taken for 6 months to 1 year) February 23, 2015
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Zonegran (zonisamide): "I have been given many different diagnosis (Hemicrania continua, primary trochlear headache, Atypical Trigeminal Neuralgia) currently I have migrainous type chronic headache with Atypical Facial Pain. I was on 300 mg Topamax with a bunch of other stuff and this helped, but I couldn't add 2 2. It was like north pole magnets coming together. Now I have been on 200mg Zonisamide (Zonegran) for about 2 years and I have a 50% reduction in pain. As for cognitive impairment, I can live with the loss of spelling and reduced vocabulary. It's not that bad compared to either the pain or Topamax."
Steve_pain November 26, 2014
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"Switched from Topamax 15 mg to Zanisamide 50 mg for 1 1/2 month. Had one migraine so far. Very bad upset stomach, acid, and burping sensation. Will hold on a little longer to see. Topamax made me lose hair. Foggy memory from both medicines."
seeking4solution (taken for 1 to 6 months) October 30, 2014
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Zonegran (zonisamide): "I took Topamax for a while and it worked wonders but the side effects were insane. However, the zonesamide works very well for preventing my migraines. I take 400 mg a day. Word finding and memory, I don't even know what those are anymore. However, I was living in constant pain. Nothing was working for me. This is the only thing that has done anything for me in years."
What memory January 12, 2014
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"I started having migraines suddenly two years after the birth of my first and only child. Sought help from a Neurologist eventually when anti-depressants prescribed by my family practice Dr didn't work. My Neuro doctor started me out on Topamax first, which I had terrible side effects from: word recall was awful and I felt paranoid and edgy all the time. Zonisamide has been a game changer. So far limited side effects: some dizziness - not bad, rash on my upper arm - not a big deal. I'll take this in exchange for the life altering migraines that pretty much shut me down any day!"
Migrainemandy (taken for 1 to 2 years) August 29, 2013
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"I did experience some appetite loss at 1st, which was OK because I wanted to loss about 5 pounds-but I started gaining weight, face was puffy, while eating very little and no decrease in exercise. The worst, however, was the onset of depression and feeling of hopelessness. I was up to 100 mg a day, on it for 2-3 weeks, and stopped cold turkey. Taking Topamax, years ago, did help with headaches and I lost weight (actually too much in beginning but body adjusted) but I also lost word facility. Not good trade off so I had to go off Topamax. Help!"
bobbi28 (taken for less than 1 month) April 20, 2013
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"I have chronic headaches (>15 per month) and tried many treatments that did not help: Botox, Topamax, and others. With zonisamide my headaches are mostly limited to just the week before my period."
Anonymous April 12, 2012
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Zonegran (zonisamide): "I've been taking Zonegran for a few years now at 300mg per day. It had really gotten my headaches under control to where I would only have a headache periodically. Weight loss has been a side effect that I haven't minded. The problem is I've had significant memory and focus issues. I hardly felt competent most of the time. I have slowly weened myself down to 100mgs per day (I notified my neurologist of this because its an anti-seizure medicine so you shouldn't stop it cold turkey or it could cause a seizure). My memory has improved significantly, but the headaches have returned with a vengeance. I'm back to taking narcotics to address each debilitating headache. I used to take Topamax. It too worked beautifully, but also wiped out the memory."
Still Looking January 4, 2012
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Zonegran (zonisamide): "I have used Zonegran for headaches only. It is the only thing that seems to have lessened them somewhat, but I still have headaches and they affect me cognitively. I'm mentally slower, have word-finding problems, my memory is bad, and my attention is terrible. I've tried to go off it on occasion, but my headaches get absolutely awful, so I stay on it."
Zonegran User March 30, 2011
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More about zonisamide
- Other brands: Zonegran