Parnate and Weight Gain: What Users Say

• Dog...
• January 16, 2020

For Depression "I have taken Parnate for 30+ years. I have low-grade chronic depression. Any time I wean off Parnate, I gain huge weight due to an out-of-control appetite, as well as lethargy and irritability that make it impossible to function. I tried 15 other antidepressants (because of severe hypertensive crises); all failed over time. Parnate is the only medication that works. I would like not to take ANY meds. I would like to be able to eat aged cheese or avocados, have a glass of good wine, and eat in a restaurant without having to do major detective work and scare the staff, but those things are not possible. Parnate is like insulin for a diabetic: it is life-preserving. Side effects you HAVE to deal with. I ended up in the emergency room twice as a result of tyramine (misled by restaurant staff). Insomnia: I take the last dose no later than 2 pm, no caffeine after morning, and when necessary, Imovane to help sleep. Loss of libido and difficulty/inability to achieve orgasm are HUGE trade-offs, but in my case, they are trade-offs for life."

• kin...
• Taken for 1 to 6 months
• December 28, 2019

For Depression "The only medication to rid me of depression, anxiety, and insomnia within weeks. But I experienced a lot of side effects: weight gain (8 kg in 6 weeks), major sugar cravings, postural hypotension, urinary retention, difficulty staying awake at random times during the day, and there were others I can’t recall. It also just stopped working on me within a few months, and I was on the max dose. Definitely recommend trying if other medications don’t work. The 'food interactions' weren’t an issue for me."

• Anonymous
• November 19, 2010

For Depression "Side effects are terrible. They include diarrhea, dry mouth, in my case weight gain, it also made me agitated. I have been trying to withdraw from it and now have neuromuscular symptoms of cramping, teeth grinding, eye blinking."