Semaglutide and Upset Stomach: What Users Say (Page 3)

• Car...
• Taken for 1 to 6 months
• July 10, 2019

Semaglutide for Type 2 Diabetes "25-year-old female taking Ozempic for PCOS and insulin resistance. I take Ozempic along with a strict paleo diet and workout regime. Started on 0.25 for 3 weeks with severe nausea and flu-like symptoms for the first 1.5 weeks. Felt terrible. Only remaining symptoms are constipation and upset stomach if I make a bad food choice. I have been taking 0.5 since May, Dr. not upping my dose to 1. Started taking Ozempic in April 2019 and was 193 lbs and last week weighed in at 177.4 lbs. Lots of people seem to have very severe symptoms, but I have been lucky and have not had any issues with ongoing problems or anything serious enough to skip work or end up in a hospital."

• Tam...
• Taken for 1 to 6 months
• August 9, 2024

Semaglutide for Type 2 Diabetes "I was scared at first, just like I guess anybody. Now from the commercials on TV about lawsuits, and you could get cancer or kidney problems, pancreatic cancer or gallbladder problems. But I ain't going to lie, I like it. It's not bothering me whatsoever. I've lost weight, my blood sugars not what it's supposed to be, but it's came down a lot. It's very expensive, thank God I've got insurance that will pay for it. But other than, you know, maybe a couple of stomach aches that I had right at first, it's leveled off and it's fine, and I'm on the lowest dose there is, my doctor said. So I'm fixing to up it, hopefully, and let's see how much weight I can lose and how much better my blood levels can get!!! I recommend you give it a try and see if it will work as good on you too. I'm not getting paid for writing this. I don't write reviews a lot sometimes, but I didn't have nothing else to do, so I thought I would... I'm 52 years old, I'm overweight, and I take metformin. Also, my blood sugar is getting better. 5⭐s"

• Ano...
• Taken for less than 1 month
• June 18, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "Lost 10 lbs in 3.5 weeks, but the side effects mean I will be stopping. Diarrhea, vomiting, stomach cramps, headaches, bloating. Felt ill most of the time. Working and traveling problematic due to having to be close to a toilet!"

• IBN...
• July 4, 2021

Semaglutide for Type 2 Diabetes "I have been on Ozempic for 3 weeks. Yes, it is making me lose weight, obviously because I'm so nauseated all the time that I can't eat. I have stomach cramps, constipation, headaches, body aches, and nausea so severe that sometimes I can't even lift my head up. I'm really trying to give it a chance since a once-a-week injection seems better than taking a bunch of pills. I just don't know how much longer I can suffer with the terrible nausea and stabbing stomach pains."

• Nan...
• September 17, 2019

Semaglutide for Type 2 Diabetes "I started a little over 2 months ago. I was excited when the doctor told me that this would help me lose weight. I was 235 at the time, and PCOS makes it hard to lose. Was warned of nausea but figured I'd be okay. Wasn't warned about sour stomach and sulfur belches. I started with the .25 mg dose. I learned what I could eat to steer clear of the sulfur burps. After 4 weeks, I moved to .5 mg and again had the sulfur burps. Had to re-learn eating limits. Last week, I moved up to 1.0 mg and didn't really have any issues until the day I was supposed to take the next dose. The discomfort was bearable. I took my injection and for the last 2 days have been nauseous. Went to bed this evening and am having trouble staying asleep. Anytime I move, the contents of my stomach shift and I feel like I'm going to be sick. 2 days prior to the last dose, I was told that my sugar has gone from the 350s to 88-120, but my weight loss is nowhere near what it should be. I hope it gets better soon."

• Mik...
• Taken for 1 to 6 months
• June 9, 2024

Semaglutide for Type 2 Diabetes "Short story is this drug worked for me! 242 lbs Started 7.4 A1C. 3mg Rybelsus. I was really trying hard. Fast food I cut and was exercising 3 days a week. I have a sweet tooth and my wife is a great baker. She had something ready for me all the time. Sunday doughnut trips. Dairy Queen etc. Cut but not cut all out. 30 days later I did lose some weight. A1C 7.0. The Doc told me the prescribing was 3mg for 30 days then 7mg. I did exercise 4 days a week and cut the sweets some more (that was hard lol). Then the magic happened. In 150 days from start 3mg to 7mg, my A1C 5.1, 195 pounds. 5 more to go. I'm 6 ft tall. I was a fat boy at 242. Now all my old clothes fit with a belt. I know this drug won't work for everyone. However, it worked for me. It will work for you if you try hard. Don't just take the drug. I do get an upset stomach from time to time but worth it!"

• JLa...
• Taken for 1 to 6 months
• May 3, 2019

Semaglutide for Type 2 Diabetes "I've been on Ozempic 0.25 for five weeks, it's great for losing weight, but the side effects are not worth it. Let me review what Ozempic has been like. The first three weeks were okay, and then I started noticing nausea, stomach burning, headache, dizziness, upper back pain, severe constipation, and feeling very tired and depressed. I ended up in the ER with a mild pancreatic attack and high lipase levels. I've had no desire to eat or even drink water. It makes me gag, and I used to drink a lot of water. I'm done with these injections. I will stay on my metformin, but I can do better on a healthy eating lifestyle than on Ozempic and all the negative side effects. Quality of life has gone from a 10 to a 1, and that is not me. I'm taking my life back. It's really just healthy eating, and we can all do that with willpower. Good luck to everyone else."

• Nik...
• Taken for 1 to 6 months
• May 7, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Checking in about my experience on Wegovy thus far. Tomorrow, Monday, May 8th, 2023, will be my second box of Wegovy 0.25 mg. So my 5th injection. I’ve lost 6 pounds since I first started. My biggest issue is diarrhea and nausea. I get occasional stomach cramping. Otherwise, I too have noticed that drinking more water seems to help. Lots of saltine crackers for me. The first week, I was scared to eat. I felt like I had the flu. It wasn’t a good experience for me. Then, gradually it let up, and by that first Friday, I felt like myself again, but still ate with caution. I have no taste! It’s odd. I know I’m eating, but it’s like I’ve lost my sense of taste. I will update after these 2 boxes are complete and hopefully will have a total weight loss that’s up to date. I don’t own a scale, lol."

• Dix...
• Taken for less than 1 month
• June 11, 2022

Semaglutide for Cardiovascular Risk Reduction "Two days after my first injection, I had horrible sulfur burps that were making me feel sick. By that evening, I had horrific stomach cramps; by 11:30 pm, I had uncontrollable diarrhea! My prescriber advised me to eat six small meals a day and that the symptoms would improve with each injection. I left it twelve days before my next one (as I had a couple of social things I didn’t want to miss if it happened again) and thought at first it was better. A headache day one, nausea on day two, but sulfur burps again by day three. I got indigestion medicine, but it didn’t even touch it. That night, same again; cramps, diarrhea, more burps, and this time intense nausea too. I decided at that point it might not be for me! I really hope it helps some people lose weight, but don’t expect a quick easy fix! I actually felt fatter the whole time I was on it as I was so bloated and tender."

• caz...
• Taken for less than 1 month
• April 5, 2023

Semaglutide for Type 2 Diabetes "I have been on the 3 mg dose and felt a bit nauseous and had a sore stomach, but it was manageable. Now going on to the 7 mg, but I am on a low GI diet as well, and this combination has helped bring my blood sugar levels down. I have problems with food addiction, and the drug helps curb the cravings by lowering my appetite. So far, I only have positive feedback about Rybelsus."

• Dog...
• Taken for less than 1 month
• March 23, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am in my first month. Had second injection last Saturday. I lost 5 pounds in the first week. Definitely curbs your appetite! I have had a small amount of stomach discomfort and gas. Hoping to continue to lose weight. I will update as time passes."

• All...
• Taken for 1 to 6 months
• March 21, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "On December 19, 2022, I saw my medical provider and requested a prescription for Ozempic. She agreed that at 5’3” and weighing 192 lbs, it would be a good option for me. I started Ozempic on January 3, 2023. The first time I weighed myself after starting Ozempic was at the beginning of February, and I weighed 179 lbs. Through February, my weight bounced between 181-175, then I lost another 5 lbs in the first two weeks of March. I’m hoping to reach 160 by mid-April. My weight goal is 130-135. I am very happy with Ozempic’s effect on my weight loss. I have had assorted side effects. I had two days of extreme headaches after my first dose, but I’ve only had mild headaches with dosage increases since. My stomach is mild to moderately upset most of the time, and most of the time I don’t have much appetite. I’m at a 1 mg/week dosage now, and I’ve started having a lot of bad-tasting burps, but constipation is by far my worst side effect. I don’t know if I would have bowel movements without laxatives."

• Not...
• Taken for 1 to 6 months
• July 24, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I started this medication about 4 months ago and have lost almost 40 lbs on it. That was great until my last dosage increase that sent me to the hospital for almost a week with little to no motility in my entire gut and pain like I have never experienced. I couldn’t keep any food down or liquids and had to be on an IV for five days straight. This medication started out working great for me with the occasional vomiting and upset stomach. I think this medication truthfully should be taken off the market for how much damage it can create, but like I said it is not for everyone, and is certainly not for me. Best advice I can give is to listen to your body!!"

• Jer...
• Taken for less than 1 month
• March 28, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am in my fourth week of Wegovy (at .25 mg). I am a female in my early 50s, 5'8", and have struggled to lose weight and need to lose 100 lbs. So far, I have not experienced any significant side effects but have seen a little more fatigue than normal, and after injection during the day only a slightly upset stomach. I have lost 13 pounds. I work out five times a week and watch/track my diet. I find that drinking a lot of water and watching what I am eating (staying at about 1,500 to 1,800 calories) with high protein helps. Because you feel full, it is a challenge to reach calories - smaller meals throughout the day help. Also, find a support group of others on the medication to get tips and ideas. I found this to be very helpful."

• Chr...
• Taken for 1 to 6 months
• March 28, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I started on Wegovy in December 2021. In the beginning, it made me sick to my stomach. I had the belching and very little appetite. When I got to 0.50 mg, oh my God! I could hardly eat anything for a couple of days. I was scared to go to the next level, but I did. When I was on the 1 mg dose, I didn't have any issues. Once I got to 1.7 mg, it wasn't bad either- a little belching, headaches for a couple of days, upset stomach, and constipation kicked in. Getting ready to start the maintenance level of 2.4 mg, and let's pray I tolerate it well. So far, I have only lost about 27 lbs, trying to lose about 17 more to get to my ideal weight. This is the best medicine that has helped me lose and, prayerfully, keep it off. I have learned how to eat small meals and make better choices in foods."

• Pum...
• Taken for less than 1 month
• August 21, 2019

Semaglutide for Type 2 Diabetes "Endo gave me a 1-month sample for type II. Just into my second week at 0.25. Initially, upset stomach and diarrhea. Wouldn't say nausea per se, more like a stomach ache. Diarrhea wasn't crampy and prolonged like metformin. Appetite really decreased. Sugars started going down about 3-4 days in, and symptoms lessened by day 6. But.... weight gain of 3 lbs! What the...? Just on day 2 of the 2nd week, no nausea, but still eating less. Not peeing as much and waking up earlier and easier, and morning sugars down from 11-12ish to 8-9ish. I will be disappointed if I am the rare one that gains weight though."

• Pum...
• Taken for less than 1 month
• August 21, 2019

Semaglutide for Type 2 Diabetes "Endo gave me a 1-month sample for type II. Just into my second week at 0.25. Initially, upset stomach and diarrhea. Wouldn't say nausea per se, more like a stomach ache. Diarrhea wasn't crampy and prolonged like metformin. Appetite really decreased. Sugars started going down about 3-4 days in, and symptoms lessened by day 6. But.... weight gain of 3 lbs! What the...? Just on day 2 of the 2nd week, no nausea, but still eating less. Not peeing as much and waking up earlier and easier, and morning sugars down from 11-12ish to 8-9ish. I will be disappointed if I am the rare one that gains weight though."

• Ann...
• Taken for less than 1 month
• May 28, 2019

Semaglutide for Type 2 Diabetes "I took my first dose of Ozempic on May 23rd. Two days later, side effects began. My stomach started burning, frequent diarrhea, and profuse vomiting. I cannot hold anything on my stomach, and I have lost over 13 lb in 3 days. The side effects are horrible. I have contacted my doctor with hopes to get relief from the side effects! The pain is horrible. I do not recommend Ozempic!"

• Sno...
• Taken for less than 1 month
• October 28, 2019

Semaglutide for Type 2 Diabetes "I just took my second dose on Friday of 0.5. I feel like garbage, no energy, tired, stomachache. I work out 4 days a week and I just can’t seem to find the energy to work out. I may stop using this drug because I’m so active and the past few days I can’t seem to do much. Appetite is gone completely. I don’t like that I have lost a few pounds but not the right way. I feel like I am starving myself, this is not for me."

• Swi...
• Taken for 1 to 6 months
• May 13, 2019

Semaglutide for Type 2 Diabetes "Started on Ozempic 5 months ago for diabetes 2. Started at 0.25, then 0.50, now at 1.00, and so far I lost weight - 35 lbs. But I’m feeling really fatigued, dizzy, and occasional stomach ache, diarrhea, and my eyesight has changed. Great drug for lowering A1C and losing weight, but the side effects are horrible. I think I’m done taking this drug. Side effects are getting worse."

• edw...
• Taken for 1 to 6 months
• January 28, 2025

Semaglutide for Type 2 Diabetes "Insurance is Medicare Advantage AARP United Health. The 1st 3-month supply was $130. The 2nd 3-month supply was $450. I expect the medication will not be affordable for the future. There was no advantage in the first 3 months taking the 3 mg dosage. A1C is 7.4% from 7.6%. Now taking the 7 mg dosage; waiting for my next doctor evaluation on Feb. 26, 2025. I get frequent headaches, dizziness, upset stomach, bloated feeling, and sleepy/low energy levels. No weight loss."

• OZ ...
• Taken for 1 to 6 months
• September 8, 2022

Semaglutide for Cardiovascular Risk Reduction "I started Ozempic for weight loss (PCOS) on June 27th. In 10 weeks, I have lost 12 lbs. It has been slow going, but I believe it's a sustainable rate so long as the medication continues to suppress my appetite. I ramped slowly up to the 1mg dose (6 weeks @ .25, 4 weeks @ .5, and then up to 1mg), which I think helped with minimizing extreme side effects. I did have nausea and occasional upset stomach the day after injecting, but it would usually subside within a day. The worst side effect I've had is an increase in acid reflux, but I've been able to manage that with omeprazole pretty well. Worth a shot if you suffer from binge eating disorder or if you are on the verge of being diabetic! Everyone's experience will vary, but I have found success with it so far."

• SAL...
• Taken for 1 to 6 months
• June 26, 2019

Semaglutide for Type 2 Diabetes "Been on Ozempic since March 2019, started off with 0.25, then 0.50, then to 1 mg. Side effects: nauseous, constipated, with fever. One month into taking Ozempic, started to have blood in my urine, no infection, CT, blood clots, bladder scope, bladder okay. CT with contrast upcoming to check kidneys, and my urine tests are concerning the PA. When giving the shot, medicine would make a bubble under the skin, then welt up 1 inch wide, 3 inches in length, and at least a .5 inch depth, 36 hours later with high fever, diarrhea, stomach cramps, large amounts of blood clots in urine, 3 times. Called Ozempic, which requested the medication back and sent a voucher for a new script. I have been taking this for 4 months, note I am not a doctor, just concerned, so I believe this could be a drug that has not been fully evaluated and may not have full understanding, or it's an odd situation for myself. However, these symptoms did not show up until on Ozempic. So for my own health, I have opted not to continue this drug."

• Drd...
• August 26, 2021

For Weight Loss (Obesity/Overweight) "I have been on this medication for two doses (0.25 mg) only and will not be continuing. Was taking it to help lose the 20-30 lbs that I need to lose and have never been sicker. The first week it made me feel slightly nauseous after eating. No matter what I ate or how much. Hours after the second dose, I started with the worst and most violent diarrhea I’ve ever had. Up all night for the fourth night last night and cannot stay out of the bathroom. Horrible stomach cramps and I’m dehydrated from the constant bathroom use. Beware…if you’re not diabetic, this drug might wreck havoc on your life. The rest of my doses are going in the trash. Just hoping these side effects pass after this week is up. It’s awful."

• All...
• Taken for 1 to 6 months
• March 15, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I took 4 shots of .25 Wegovy. The first shot had no side effects and no problems. The second shot was a little different. Mild upset stomach starting about 24 hours afterward with some stomach pain. This subsided within the third day. My appetite was suppressed, felt fuller for longer. In the third shot, I had no appetite with stomach pain that lasted two days, and also felt as if I were going to pass out. I drank orange juice and ate saltine crackers with peanut butter, which helped. The last .25 shot of Wegovy… I had lost 12 pounds by this shot. But within a day, I was projectile vomiting, upset stomach, extreme pain in my abdomen, chills, and dizziness. I was taken to the emergency room. I was diagnosed with colitis that had gone to sepsis. The doctor explained a side effect from Wegovy may cause gastrointestinal problems. Wegovy attacked my colon and in turn, sepsis formed. I will not continue this shot. So many side effects go with it. It does curve your appetite, but I would be very cautious."