Semaglutide and Upset Stomach: What Users Say (Page 2)

• Weg...
• Taken for 1 to 6 months
• March 20, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Started with Ozempic .25 ml dosage and have ramped up to 1 ml dosage over 3 months. They started me on Ozempic due to the shortage of Wegovy back then. Today I start Wegovy at 1.7 ml and I'm not even on the maximum dosage yet. I just got back from the doctor and I have lost 9.5 percent of my body weight, my blood pressure is way down, and my A1C level has gone from 7 to 5.8 in that time! One drawback is that I have had significant stomach issues with this drug that come and go. Forget about eating anything spicy or heavy at night, and it does curb your appetite, big time. I probably eat half as much as I used to. Overall, it is the best thing that has happened to me."

• Jim...
• Taken for 1 to 6 months
• July 28, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "The first four weeks on the .25 dose I lost a few pounds. The next 8 weeks on the .5 dosage I lost about 5 lbs, but then I plateaued and my weight actually increased. My Dr. increased the dosage to 1.0, which I have been on for the last 10 days. I have not lost any more weight. My opinion is that this drug may be helpful to some, it didn't help me. I was buying the drug from Novo Care at a cost of $500 per four doses and have spent a total of $2,000 to date. I have 2 doses in the refrigerator, but I am not going to use them. What I realized was a 12 lb weight loss, severe lethargy, stomach discomfort, and severe constipation. Conclusion: Not worth the money or effort. The side effects far outweigh the benefits."

• Ter...
• Taken for 6 months to 1 year
• January 12, 2025

Semaglutide for Cardiovascular Risk Reduction "My experience with Wegovy. - Experienced upset stomach and nausea initially, but these symptoms were manageable. - Lost 32 pounds in six months, with reduced appetite as a significant benefit. - Knee issues have limited exercise, but weight loss has contributed to lower blood pressure. - Monthly cost is around $200, with insurance coverage easing the financial burden. - Wegovy's injection is easy to use and comes with excellent support and reminders."

• oag...
• Taken for less than 1 month
• June 13, 2023

Semaglutide for Type 2 Diabetes "This is terrible. It is my second time trying to take this medication. I have experienced vomiting, stomach ache, sweating, and chills. I feel so bad that I am not going to try 'to get used to this medication.'"

• Dke...
• Taken for 1 to 6 months
• May 19, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I had high hopes for this drug and stuck with it as long as I could, but it caused severe constipation, stomach cramping, and fatigue. I started out with .25 mg for 4 weeks, then .50 for 2 weeks. I didn’t lose weight, so my doctor increased the dose to 1 mg, but I just couldn’t tolerate the side effects at the lower doses, so I didn’t even try the 1 mg."

• Typ...
• Taken for 1 to 6 months
• May 16, 2023

Semaglutide for Type 2 Diabetes "I am on my 3rd month of taking Ozempic. No decrease in A1C as of yet. Weight loss, none. Ease of use, I find handling the needles cumbersome. The needles are smaller than Trulicity and less painful to inject. Less bruising at the injection site. Current side effects: nausea, stomach pain, stomach discomfort, swelling, bloating, increased constipation, increased hunger, sour stomach, headaches. I find I am forced to take additional medication/supplements in attempting to eliminate some of the side effects. I've taken stool softeners and laxatives in order to improve constipation with limited success. I am taking a pain reliever almost daily for headaches. I am also taking medication to help ease the nausea with limited success."

• Typ...
• Taken for 1 to 6 months
• May 16, 2023

Semaglutide for Type 2 Diabetes "I am on my 3rd month of taking Ozempic. No decrease in A1C as of yet. Weight loss, none. Ease of use, I find handling the needles cumbersome. The needles are smaller than Trulicity and less painful to inject. Less bruising at the injection site. Current side effects: nausea, stomach pain, stomach discomfort, swelling, bloating, increased constipation, increased hunger, sour stomach, headaches. I find I am forced to take additional medication/supplements in attempting to eliminate some of the side effects. I've taken stool softeners and laxatives in order to improve constipation with limited success. I am taking a pain reliever almost daily for headaches. I am also taking medication to help ease the nausea with limited success."

• Fan...
• Taken for 1 to 6 months
• October 5, 2020

Semaglutide for Type 2 Diabetes "I have been on Rybelsus for 1.5 months. Can’t eat, and what I do eat makes me so nauseous that it all comes back up. I have lost 10 lbs, which is great, but if this upset stomach and throwing up do not go away, then it is not worth it. I’ll give it another week, but I think I will tell the doctor I am done. My sugar levels were high, and that is why he prescribed it to take along with Synjardy. Feeling sick all the time is not worth it."

• Ker...
• August 16, 2020

Semaglutide for Type 2 Diabetes "I started using Ozempic 2 weeks ago. I don’t have any major side effects. Occasional upset stomach, but nothing too terrible. I am hoping to stay on this meds even though my insurance isn’t covering it."

• Bet...
• December 15, 2019

Semaglutide for Type 2 Diabetes "I started Ozempic two months ago. At first, I was okay, just a little stomach discomfort. But over the last 3 weeks, things have gotten horribly worse. I can't eat without feeling sick. And explosive diarrhea started. I feel like I have horrible food poisoning. I will never take this drug again."

• Uni...
• May 27, 2021

Semaglutide for Type 2 Diabetes "I'm on my second week. I've lost 2-3 lb. I feel less hungry and don't lose control after I eat. I don't constantly think about food. If I overeat, I feel sick after. I still want sweets, but I can eat very little and feel content, almost put off by it. I feel the most side effect symptoms right after the injections. The side effects have been mild, probably because I put the injection into my thigh instead of my stomach. They include: bowel movements, weird taste in mouth, headaches, tiredness, tummy ache, and earache. But very mild. I'm excited to move up to a full dose."

• Ann...
• Taken for less than 1 month
• March 25, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I have been taking Ozempic for three weeks, and the first week wasn't so bad with the stomach cramps (off and on). Second week, the cramps were the same, but diarrhea got worse. By the third week, the cramps are worse, and the diarrhea is seriously worse after every meal (watery). Obviously, I will discontinue use at this point. However, I do have an underlying condition: IBS-D. Just for your information. Good luck to all."

• Tim...
• Taken for less than 1 month
• June 5, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "Tuesday was the second shot. So far, no headaches, just upset stomach now and then. I really like that it takes all hunger away. Now I just focus on eating healthy and much less. I'm a 60-year-old man, started at 293 lbs. Tuesday, before the shot, I weighed 283. I feel better when I drink water, which I drink at least 10 bottles a day. Eat more fruit and veggies."

• Sug...
• Taken for less than 1 month
• September 20, 2019

Semaglutide for Type 2 Diabetes "Took my first dose of .25 on 9/11 with no side effects at all. When I took the second dose was when everything went bad. After about 1 hour after the 2nd dose, I noticed my stomach started tightening up, so I didn't think much of it until I started driving and vomiting all over the place. Was vomiting for about 12 hours, then started getting bad stomach cramps. Today is 9/19, and I decided that I'm not taking this no more and wouldn't recommend this to anyone, not even my worst enemy. THIS STUFF IS NOT GOOD AT ALL!!"

• Bre...
• Taken for 1 to 6 months
• May 26, 2024

Semaglutide for Type 2 Diabetes "Started with the 0.25 dose & after 5 weeks went to 0.50. Side effects were minimal, mostly just an upset stomach for the first day after a shot. Pens were easy to use & directions easy to follow. My A1c went from 10.3 to 6.2 after 90 days & I lost 22 lbs. I made significant dietary changes, which were helped because overeating gave me that 'too full to move' feeling you get on Thanksgiving, even with small portions. I eat 4-5 times a day but in small portions & calories under 1200 daily. Constipation was avoided by an increase in fiber/vegetables and water."

• Mon...
• Taken for 6 months to 1 year
• August 15, 2019

Semaglutide for Type 2 Diabetes "Started Ozempic in January 2019. I have lost 24 lbs, and my A1C has gone down. My appetite has been cut in half. The only side effect I have had was in the beginning: slight headaches. Those have gone away. If I overeat, I’ll get a sour stomach. But other than that, I didn’t get those bad effects I have been reading about. Definitely happy with the results."

• Jpa...
• Taken for 1 to 6 months
• July 15, 2019

Semaglutide for Type 2 Diabetes "I’m into my 5th week and have increased to .5. In addition to diabetes type 2, I have PCOS and IBS. I’ve been doing well so far, other than a mild headache and stomach upset. My appetite is obliterated, and I have to make sure I’m eating regularly. Otherwise, nausea and lightheadedness end up being my trigger to eat because I’ve gone too long in between meals. It’s been confusing for me, as overeating has always been an issue. Now I have no desire to eat and am working at adjusting by eating small portions throughout the day. I’m definitely losing weight, which is much needed. In addition to Ozempic, I take Metformin and Tradjenta, which I’ve been on for a very long time. This week, my fasting blood sugar decreased from 155 to 135. That makes me happy."

• mew...
• Taken for 1 to 6 months
• August 27, 2024

Semaglutide for Type 2 Diabetes "I’m 63 F with T2 diabetes, and I started on Oz mid-May 2024. Symptoms: nausea, fatigue, GERD, sulfur burps, stomach cramping from severe constipation, constipation, feeling like I need to vomit, ringing in my ears has increased significantly, loss of appetite, reduction of inflammation, occasional migraines, feeling “off” most days, bouts of dizziness, and feeling faint, but blood sugar and blood pressure are normal, improved blood sugar readings, weight loss of 13 lbs. There are some perks: rheumatoid and osteoarthritis inflammation has lessened, though I still feel pain daily, it’s more tolerable. I take no painkillers but will take CBD as needed. Loss of appetite has led to a loss of 13 lbs so far, blood sugar improved so I’m confident that my A1C has improved also. I struggle with what to do: stay on for the inflammatory reductions, weight loss, and blood sugar improvement benefits, or quit because I feel sick most days, so I have no real pleasure in life anymore. No, I’m not depressed."

• rac...
• Taken for 1 to 6 months
• March 27, 2021

Semaglutide for Type 2 Diabetes "Been on Rybelsus for 3 months, along with Metformin and Glyburide. Overall, it has been great, with morning sugar in the 130 range from the 180s before. Haven’t done A1C, but I’m hopeful. Some stomach issues - feel bloated a lot, and one time had dry heaves. But I’ve adapted and found just eating less avoids the issues. A side benefit is lost about ten pounds without any effort, really. Only real issue is cost, Medicare coverage sucks on this drug."

• Jen...
• Taken for less than 1 month
• June 29, 2025

For Weight Loss (Obesity/Overweight) "I’m a 47-year-old female who gained 30 pounds over the last 2 years after I quit smoking and drinking. I’m at my highest weight of my life. I’m 5’6” and currently 215 lbs. I’m starting semaglutide next week, but I’m extremely scared of the side effects. I have stomach issues and acid reflux as it is, and these reviews have me terrified. I’m going to give it a shot (see what I did there) and see what happens. I’ll update here weekly with what’s happening. Wish me luck!"

• Ano...
• Taken for 1 to 6 months
• May 7, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I lost 25 lbs on a 0.25 Wegovy dose between February 25th and May 7th (about 10 weeks). I went from 178 lbs to 153 lbs. I am a male, 5'6''. I was already exercising for 45-50 minutes a day for 6 days a week, but I could not lose the weight. Wegovy helped me control my appetite mentally, resulting in fewer calorie intake, and boom, the weight started to come off. I also have fatty liver disease and have recently seen some studies showing promising results with this drug. I sometimes have mild bloating and stomach cramps, but not extreme."

• NP2...
• Taken for less than 1 month
• July 24, 2021

Semaglutide for Type 2 Diabetes "28 days in! Started on 7 mg and will continue with 7 mg. I am also on Metformin 500 mg daily and have been for years. To be fair, my A1c was never above 6.3, and my weight was 179 lbs and height is 5-6. I have a strong family history of insulin-dependent diabetics, and I don’t want to go there! I’ve been losing weight like crazy with no exercise, which is why I came to read some of these reviews to see if this is common. Current weight is 164. Lost 15 lbs in 28 days! Mild nausea and dry mouth after taking the med in the morning. Pill is also bitter and not overly large, but a little hard to swallow. Nausea disappears with ginger ale or fruit. Appetite is gone! I have to force myself to eat at times. I suggest a vitamin supplement. Mild stomach ache and loose stool later in the day, but have solid soft stool in the morning. Want to continue to reach the weight goal of 155 lbs and A1c below 5.8. Then maybe go to a reduced dose if necessary. I definitely recommend this drug."

• M J...
• Taken for less than 1 month
• August 16, 2022

Semaglutide for Cardiovascular Risk Reduction "I started with 0.25 at 170 lbs and was hopeful. 1st and 2nd injection, no problem, I thought, but I had gained 2 pounds, very constipated. 3rd injection, everything changed, less than 12 hours, the worst stomach cramps ever, on the stool every 20 minutes for the next 10 hours, bearing down so hard it was like labor pains. I started passing blood, and my urine became so dark it looked like apple juice. I took the last injection on Friday, that problem did not clear up until late Tuesday afternoon. I did call the doctor, he put me on antibiotics. There is no reversal for this medication. It was not for me."

• Nei...
• April 16, 2021

Semaglutide for Type 2 Diabetes "Month 1, I was started on Ozempic at 0.25 mg and had very mild symptoms of bloating and reduced appetite. Month 2 & 3, uncomfortable. Stomach cramps, gas, and diarrhea probably for 4 days after injection. This can be really embarrassing in a small office. By the end of Month 3, I was feeling quite a bit better. At this point, my HbA1c was down to 5.2 from 9.4, I had virtually no diabetic symptoms. No blurred vision, no numbness in fingers and toes, and I was sleeping through the night without visits to the bathroom. And I lost 16 kilo in weight. Month 4 to 7. OMG. Increasing to 1 mg, the side effects are horrendous. Weight loss has stalled, though this is probably due to lockdown. The sickness and eggy burps are constant, and now my doctor says it will be at least 6 months before the side effects could be gone. But I have no diabetic symptoms, my HbA1c is pretty much normal, and I think the effort has been worth it. Not an easy journey, but worthwhile."

• Sna...
• Taken for 6 months to 1 year
• August 20, 2019

Semaglutide for Type 2 Diabetes "Been on this for almost a year. Have had type 2 for 18 years now. A1C's always in the 6.5-7.5 range. Was primarily using Humalog to control BS. With Ozempic, sugars stay lower. The peaks aren't as high, and don't have to use as much insulin. The only side effect I get is diarrhea and stomach cramps (mainly gas buildup) 12-48 hours after taking it. On occasion, I will get nauseated. I have stayed on .25 and never increased. So far, I like this drug, and those side effects are manageable. As long as I'm near a toilet the first 48 hours, just in case."