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Semaglutide and Stomach Pain: What Users Say (Page 4)

Brand names: Ozempic, Rybelsus, Wegovy

Reviews for Semaglutide

Commonly mentioned side effects
  • Ron...
  • Taken for 1 to 6 months
  • March 23, 2022

Semaglutide for Cardiovascular Risk Reduction "I started Ozempic for weight loss, started with 0.25, then 0.5, then 0.75, all this in 7 weeks. I lost 7 kilos in 6 weeks. But I was extremely nauseated and exhausted most of the time. Another thing I found and would love to know if anyone else experienced it. It extremely triggered my adenomyosis. I was constantly bleeding and had severe stomach and back pain. I just got off Ozempic to see if it will settle. Apparently, they say bleeding has nothing to do with it, but when I missed an injection after a few days, everything settled. I think this is an unreported, maybe rare side effect."

5 / 10
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  • Wen...
  • Taken for 1 to 6 months
  • March 8, 2022

Semaglutide for Type 2 Diabetes "I have been on Ozempic at the lowest dose for 4 weeks. The first week was brutal, with stomach pain, nausea, vomiting, and headache, however, I injected the second week in my thigh and the side effects waned. It appears to be lowering and leveling my A1C. I'm nervous about increasing my dose next week. I can manage a week of discomfort as long as it is short-term. My body does seem to be getting used to it. I'm willing to work with it as long-term benefits for me outweigh the short-term discomfort. I may change my mind as time goes on, as these horror stories have me concerned. So strange that there is such a wide range of patient experiences...both good and bad."

5 / 10
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  • Ell...
  • Taken for 1 to 6 months
  • July 27, 2021

Semaglutide for Cardiovascular Risk Reduction "First 4 weeks fine, but upping to 0.25 and then 0.5 was the worst experience. Horrible sulfa burps, indigestion, vomiting to the point water isn't tolerated. Stomach pains. Ended up in the hospital. Wanting to come off ASAP. Not worth it at all. Can't eat, in pain and vomiting. The burps and vomit are acid, it stinks, hurts, and burns. Not worth it for 7 kg lost."

5 / 10
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Frequently asked questions

  • jam...
  • Taken for 1 to 6 months
  • June 2, 2021

Semaglutide for Type 2 Diabetes "I have been on 0.5 Ozempic for 2 months now. The nausea is no better. I vomit almost every day. Driving down the road and I begin to vomit. Almost caused me to wreck my car twice now. I've lost 30 pounds and feel terrible. My stomach hurts all the time and now my back. I do not urinate much at all even though I've increased water. Calling today and going off it. Losing weight is great, but not at the cost of feeling horrible every day."

5 / 10
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  • Car...
  • Taken for 1 to 6 months
  • April 24, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am on week 4 of Wegovy, the first 2 doses were 0.25 mg. The last 2 were 0.5 mg. I've had stomach pains and nausea to the point I'm in tears, it aches so much. My weight is going from 221 lbs to 215 lbs, I'm 5'9". I hardly eat for fear of worsening stomach issues. While my pharmacist says the side effects should go away by now, they haven't. I also have no energy, want to sleep, and have a hard time getting my blood sugar above 98, that's after a healthy meal with protein and a vegetable. Not sure this is worth it."

4 / 10
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  • All...
  • Taken for 1 to 6 months
  • March 15, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I took 4 shots of .25 Wegovy. The first shot had no side effects and no problems. The second shot was a little different. Mild upset stomach starting about 24 hours afterward with some stomach pain. This subsided within the third day. My appetite was suppressed, felt fuller for longer. In the third shot, I had no appetite with stomach pain that lasted two days, and also felt as if I were going to pass out. I drank orange juice and ate saltine crackers with peanut butter, which helped. The last .25 shot of Wegovy… I had lost 12 pounds by this shot. But within a day, I was projectile vomiting, upset stomach, extreme pain in my abdomen, chills, and dizziness. I was taken to the emergency room. I was diagnosed with colitis that had gone to sepsis. The doctor explained a side effect from Wegovy may cause gastrointestinal problems. Wegovy attacked my colon and in turn, sepsis formed. I will not continue this shot. So many side effects go with it. It does curve your appetite, but I would be very cautious."

4 / 10
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  • kee...
  • Taken for 6 months to 1 year
  • September 15, 2022

Semaglutide for Type 2 Diabetes "On Rybelsus for almost a year. My A1c has improved from an 8.1 to 7.2. However, I have not lost any weight as most people have. I have chronic constipation. My gastro advised a low fiber diet -- yes, low fiber -- and laxatives every other day. My daily numbers are all over the place. When I do finally have a bowel movement, I have stomach pain followed by diarrhea. Next time I go, I'll ask what alternative medicine I could try. I can't take metformin because after many years on it, I started to have stomach problems, and eliminating metformin helped greatly."

4 / 10
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More FAQ

  • Mam...
  • Taken for 1 to 6 months
  • February 14, 2020

Semaglutide for Type 2 Diabetes "I have been on Ozempic for about 4 months. Throughout the whole experience, I lost about 10 pounds, of which 4 came back. My labs improved a lot, A1C went from 6.4 to 5.8, and triglycerides went down to a completely normal level for the first time in 30 years. This med turns off your hunger cravings and works really well. Unfortunately, I have been plagued with nasty side effects from the start that I didn’t realize were from the Ozempic. These range from nausea and bad stomach pain to some sort of inflammatory gout-like response in my joints. Also, I went for my yearly eye check, and for the first time, I was told that the pressures in my one eye are high, and now I have to see a specialist for possible glaucoma. I decided earlier in the week, after my last dose of 0.5 mg (I wanted to see if my joints would swell again, and they did), that I am done with this med for good. Usually, the swelling and pain go away, but then if I take Ozempic again, it all starts again. I have had enough."

4 / 10
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  • Jus...
  • Taken for less than 1 month
  • May 13, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started Ozempic .5 mg once a week. I have taken it for 3 weeks. I have had to stop it because I have been so sick. I have had massively bad headaches, nausea, vomiting, and stomach pain. After the first injection, I ended up in the ER because of my stomach pain, and then again 5 days later. I haven't been able to keep anything down. I can barely keep 2 sips of water down. I can't even take any of my prescription medications because I am constantly throwing them back up. My doctor told me to stop taking it. My husband says I've lost weight, but that's only because I'm constantly throwing everything up."

3 / 10
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  • Lis...
  • Taken for 1 to 6 months
  • January 29, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy 8 weeks ago. The coupon made it $25 a month. On the dose of 0.25, I had nausea and occasional diarrhea. On my 7th injection dose of 0.5, I got very sick: extreme nausea, diarrhea, and stomach pains. I skipped my next dose. I have been to the emergency room twice for fluids and anti-nausea medicine. The diarrhea is the worst of it-nonstop. I cannot keep anything down. I am down 23 pounds but feel miserable. I hope the medication wears off soon. I do not recommend the medication, it makes you feel so sick."

3 / 10
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  • kee...
  • Taken for 1 to 6 months
  • October 15, 2021

Semaglutide for Type 2 Diabetes "I am on 3 mg for a month, constipation and stomach pain, occasional vomiting. The next month, 7 mg and side effect symptoms are worse: belching, rotten-tasting burps, stomach pain, vomiting food still on my stomach 24 hours later. I will try to persevere since some people say it gets better. Not going up to 14 mg next month till I see my A1C levels. My daily numbers are better, but I feel like I'm wrecking my digestion."

3 / 10
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  • Her...
  • Taken for 1 to 6 months
  • April 28, 2021

Semaglutide for Type 2 Diabetes "I am a 54-year-old overweight male who started taking Ozempic 3 months ago to help control my type 2 diabetes and to lower my A1C. For the first 3 weeks, I took a 0.25 dose weekly and felt okay. Some occasional stomach cramps and nausea. For the past 2 months, I have been taking a 0.50 dose, and side effects have gotten worse. Loss of appetite, stomach pains, feeling nauseous, and uncontrollable diarrhea while sleeping. Yes, that's right... I have been pooping the bed. On the plus side, I have lost over 20 lbs, but at quite a disgusting price to pay. Time to either quit taking this or try something else. I now understand the commercials where the people say 'O.' It's because 'O, I pooped my pants again.'"

3 / 10
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  • Eur...
  • January 25, 2021

Semaglutide for Type 2 Diabetes "Started the Ozempic injections about 4 months ago. I did okay on the .25 dose. After 3 weeks, the doc had me do the .50 dose. I had chronic stress for 3 months (dog had cancer), so I lost myself in caring for her. After her death, I felt the effects of the RX. I had the worst sulfur burps and gas, stomach pain, bloating, and nausea I'd ever had in my life. I stopped the RX, changed to a low sulfur diet, and that didn't work, so I did a slow stomach emptying diet. After 1.5 weeks, my sulfur and gas/bloating cleared up, and I felt normal. I had a doc appointment and told him about the sulfur issues and what I did to stop it. He said I had lost 20 pounds, A1C went down to 6, and he wanted me back on it. I took another injection, and 2 days later, here I am with bad sulfur burps, gas/bloating, nausea, and stomach pain. I guess I'm going to have to eat very little to keep my stomach empty to make my doc happy-while I suffer. Not thrilled but willing to try a while longer to see if weight loss and A1C continues."

3 / 10
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  • Dor...
  • Taken for 1 to 6 months
  • December 21, 2020

Semaglutide for Type 2 Diabetes "I started taking Rybelsus 3mg. I was nauseous at first and constipated. I was also belching a lot. After 2 weeks, that seemed to stop. I've been on the 7mg for 17 days and the nausea, indigestion, stomach pain, and now diarrhea have been almost unbearable and are getting worse. I've also started feeling panicky and anxious in the middle of the night with rapid heartbeat. I'm stopping the 7mg tomorrow and calling my doctor. I can't feel like this at Christmas. Going to see if she will put me back on 3mg. My A1C was 9.0. I have no idea what it is now. I've also lost 18 lbs because I can barely eat anything. This isn't worth it."

3 / 10
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  • Lau...
  • Taken for 1 to 6 months
  • April 1, 2020

Semaglutide for Type 2 Diabetes "I have been prescribed Ozempic for weight loss secondary to type 2. I got nauseated with some loss of appetite at 0.25 mg dosage and adapted to it over a month. Lost 9 lbs in that month. I increased to 0.5 mg last Friday (it is Tuesday), and I am miserable. Non-stop nausea, burping, some pain in the stomach, constipated. I feel miserable. I am worried about the stomach pain being pancreatitis starting, so I am increasing my water. I haven't eaten in two days. I will not continue with this drug as I think this just cannot be a good thing to do to one's body."

3 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • February 25, 2024

Semaglutide for Type 2 Diabetes "I was doing okay at the beginning, but when the dose increased at about the one-month mark, I experienced severe stomach and indigestion problems. I went to emergency, and the doctor recommended that I not double the dose, but remain at the initial dose. I did that for about 6 months. Then I developed major stomach pain, indigestion, and constipation. I went to emergency again and was given medication, as I did at my initial hospitalization. I have now stopped taking Ozempic because it does not work for me, and there are too many severe side effects. I would not recommend this medication to anyone due to my own personal experience from using it for 6 months."

2 / 10
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  • hal...
  • Taken for less than 1 month
  • June 4, 2023

Semaglutide for Type 2 Diabetes "The major side effects are all I got with this med, which includes upset stomach, heartburn, burping, gas, bloating, nausea, vomiting, stomach pain, loss of appetite, stomach flu symptoms, headache, dizziness, and tiredness."

2 / 10
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  • BJB...
  • Taken for 1 to 6 months
  • May 20, 2023

For Weight Loss (Obesity/Overweight) "I started using semaglutide for weight loss at the lowest dose, and each 4 weeks raised the dosage. I did not lose a single pound in all that time. I am a yoga instructor and practice 4 times per week. I became so severely constipated that I ended up in the ER. I battled with very severe fatigue, weakness, at times overly hungry, blurry vision, and a feeling of just being 'out of it.' I feel like I lost 3 months of my life. After taking my last dose 9 days ago, I’m still having bouts of diarrhea, stomach pain, and headaches. It was not worth it at all for me."

2 / 10
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  • Don...
  • Taken for 1 to 6 months
  • March 13, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I have had severe nausea and stomach pains, constipation, and back pain. Have had to stop taking it."

2 / 10
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  • Nev...
  • Taken for less than 1 month
  • September 7, 2022

Semaglutide for Cardiovascular Risk Reduction "I just started this medication a couple of days ago, and I will never inject this medication into my body again. These stomach pains are worse than labor. Never again. Been to the emergency room twice, and I’m still in extreme pain."

2 / 10
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  • Rav...
  • Taken for 1 to 6 months
  • June 2, 2022

Semaglutide for Type 2 Diabetes "Bad stomach pains and nausea/diarrhea the day of the shot and for a day or two after, and extreme tiredness. On week 8 and .50 dose. Hardly can eat solid foods, full within 4 or 5 bites, but not losing weight as promised- I don't like it so far, just misery!"

2 / 10
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  • Sar...
  • Taken for less than 1 month
  • October 17, 2021

Semaglutide for Type 2 Diabetes "My A1C was slowly creeping up, and at 6.9, the Dr. wanted to start Rybelsus (3 mg). I took it exactly as directed. The side effects were immediate: constipation followed by diarrhea and extreme nausea. As I continued on the medication, nausea was constant and actually turned into stomach pain. If I ate anything, my stomach hurt worse, and I started to have an aversion to food. Any activity or exercise that involved using my core muscles was very painful. Still, I persevered knowing that it can take a few weeks to adjust to a medication. But in week 3, after side effects continued to worsen and I vomited for several days in a row, I stopped the medication. I have been off for 3 weeks now, and my stomach has not returned to normal as I have constant discomfort and it hurts after eating. I lost 10 lbs in 3 weeks, but it came at a high cost. The physical side effects were extreme, and I hope I have not permanently harmed my body. I can still only eat a few bites at any one time. Beware!"

2 / 10
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  • Ann...
  • Taken for 1 to 6 months
  • July 18, 2021

Semaglutide for Type 2 Diabetes "I started this drug to try and lower my A1C, which had climbed to 7.2. My nurse practitioner put me on it. She showed me how to do the injections, but no warnings of side effects. I took a .25 dose for 4 weeks, suffering pain in my stomach that radiated to my back. Absolutely no craving to eat anything at all. Had constipation. Then I went to a .5 injection and was fine for a bit until severe nausea began, along with dizziness and vomiting. I thought it was going to be the end of me, because then the unrelenting diarrhea began. I waited days in bed, so very ill, and decided to quit this awful medication. I have lost 6 pounds, and my morning glucose numbers are 107, it's lower, but feeling this deathly ill just isn't worth it. I quit the medication, though I understand it could take 5 weeks to leave my body. Beware of this drug."

2 / 10
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  • Cha...
  • Taken for 1 to 6 months
  • March 25, 2021

Semaglutide for Type 2 Diabetes "Please stop taking Ozempic. I have been taking it for 12 weeks, started with 0.25 for the first 4 weeks, then moved on to 0.50. First 4 weeks, minor side effect, but my pulse rate started to go up resting from 65 to nearly 80. Once I started the 0.50 dose, I started to lose weight, lost 1 stone in 8 weeks, but suffered so much: vomiting, constipation, stomach pain, dehydration, depletion of magnesium in body, and resting heart rate to 94. Was hospitalized last week and was on a drip for 2 days. I have decided to stop taking it, my next injection is due in 2 days. I am hoping stopping does not cause other issues, I will revert to taking insulin. So please do not start this drug. There are other options to manage your diabetes."

2 / 10
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  • Cor...
  • Taken for 6 months to 1 year
  • March 23, 2021

Semaglutide for Type 2 Diabetes "Great drug for appetite loss. Only lost 8 kg in 6 months' time. A1C was better for sure! However, if one has GI issues, this drug is nasty! I take Omeprazole due to acid reflux, but with the combo, good lord! It caused me to have the worst stomach pain that went to the right side and around to the middle of my back. That was at the 6-month mark. I went off as I am being sent for an ultrasound on my liver and pancreas. Never had that issue before! Three days after no injection, the pain got less and now two weeks off. No stomach or back pain. Never again! I have been struggling with my diabetes health care center for several years for a good balance. I eat well, exercise, etc. One big downfall when you go off of it: your appetite increases more than before taking the drug. It is just vile!"

2 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.