Ozempic and Upset Stomach: What Users Say

• Jan...
• Taken for 1 to 6 months
• March 15, 2021

For Type 2 Diabetes "My doctor gave me Ozempic 0.5 to start with. I always had upset stomach, diarrhea with most foods, and an overall sick feeling all the time. I was able to 'live' with it until now. She decided to up my dose to the 1.0 and my body went into total chaos. I am always nauseous, constipated, got reflux, feels like my food is stuck in my stomach and doesn't go anywhere. I'm constantly burping and feeling bloated. The sick feeling feels intensified and I cannot function at work. I took my last one this past Friday night and was miserable all weekend long. Today I am at work unable to function at my best because the nausea is bad. I would say it is effective in lowering your blood sugar numbers and helping you lose weight but not worth feeling horribly sick over. I will not be using this medication any longer."

• Cat...
• Taken for less than 1 month
• July 10, 2019

For Type 2 Diabetes "First injected dose Sunday night. Wee hours Monday, the nausea started. No vomiting (emetophobic here!) Monday all day nausea that I could handle (took a Zofran). Tuesday afternoon hit with sudden stomach cramping and diarrhea. Those nasty sulfuric burps all Tuesday evening and overnight, diarrhea all night, and now it’s Wednesday morning and still watery diarrhea. My stomach has been rumbling and terribly bloated since Tuesday afternoon. I need to lose 70 lbs, but this is NOT worth it!! Who wants days and weeks of feeling HORRIBLE!?! I’ll lose weight another way! I have sleep apnea and am 56, so I want to be healthy, but this drug is not recommended unless you need to lose weight to stay alive. I teach too, so there’s no way I can continue this."

• Typ...
• Taken for 1 to 6 months
• May 16, 2023

For Type 2 Diabetes "I am on my 3rd month of taking Ozempic. No decrease in A1C as of yet. Weight loss, none. Ease of use, I find handling the needles cumbersome. The needles are smaller than Trulicity and less painful to inject. Less bruising at the injection site. Current side effects: nausea, stomach pain, stomach discomfort, swelling, bloating, increased constipation, increased hunger, sour stomach, headaches. I find I am forced to take additional medication/supplements in attempting to eliminate some of the side effects. I've taken stool softeners and laxatives in order to improve constipation with limited success. I am taking a pain reliever almost daily for headaches. I am also taking medication to help ease the nausea with limited success."

• Typ...
• Taken for 1 to 6 months
• May 16, 2023

For Type 2 Diabetes "I am on my 3rd month of taking Ozempic. No decrease in A1C as of yet. Weight loss, none. Ease of use, I find handling the needles cumbersome. The needles are smaller than Trulicity and less painful to inject. Less bruising at the injection site. Current side effects: nausea, stomach pain, stomach discomfort, swelling, bloating, increased constipation, increased hunger, sour stomach, headaches. I find I am forced to take additional medication/supplements in attempting to eliminate some of the side effects. I've taken stool softeners and laxatives in order to improve constipation with limited success. I am taking a pain reliever almost daily for headaches. I am also taking medication to help ease the nausea with limited success."

• Nei...
• April 16, 2021

For Type 2 Diabetes "Month 1, I was started on Ozempic at 0.25 mg and had very mild symptoms of bloating and reduced appetite. Month 2 & 3, uncomfortable. Stomach cramps, gas, and diarrhea probably for 4 days after injection. This can be really embarrassing in a small office. By the end of Month 3, I was feeling quite a bit better. At this point, my HbA1c was down to 5.2 from 9.4, I had virtually no diabetic symptoms. No blurred vision, no numbness in fingers and toes, and I was sleeping through the night without visits to the bathroom. And I lost 16 kilo in weight. Month 4 to 7. OMG. Increasing to 1 mg, the side effects are horrendous. Weight loss has stalled, though this is probably due to lockdown. The sickness and eggy burps are constant, and now my doctor says it will be at least 6 months before the side effects could be gone. But I have no diabetic symptoms, my HbA1c is pretty much normal, and I think the effort has been worth it. Not an easy journey, but worthwhile."

• Dix...
• Taken for less than 1 month
• June 11, 2022

For Cardiovascular Risk Reduction "Two days after my first injection, I had horrible sulfur burps that were making me feel sick. By that evening, I had horrific stomach cramps; by 11:30 pm, I had uncontrollable diarrhea! My prescriber advised me to eat six small meals a day and that the symptoms would improve with each injection. I left it twelve days before my next one (as I had a couple of social things I didn’t want to miss if it happened again) and thought at first it was better. A headache day one, nausea on day two, but sulfur burps again by day three. I got indigestion medicine, but it didn’t even touch it. That night, same again; cramps, diarrhea, more burps, and this time intense nausea too. I decided at that point it might not be for me! I really hope it helps some people lose weight, but don’t expect a quick easy fix! I actually felt fatter the whole time I was on it as I was so bloated and tender."

• Bub...
• Taken for 1 to 6 months
• August 28, 2019

For Type 2 Diabetes "I have been on Ozempic for 9 weeks. I have not increased my dose due to stomach issues, I just stayed at .25. My A1C is starting to come down slowly. Have a 3-month check-in in 2 weeks. It was 10.2, then dropped to 9. I do feel weak and dizzy, and I dropped low in the morning and at night. Sometimes in the middle of the day. Yes, I am bloated. My weight was 220, lost 4 lbs, and I gained weight, so then 222. I have lost weight and I am down to 217. Hope this weight loss continues."

• Cpa...
• July 1, 2019

For Type 2 Diabetes "I've been taking Ozempic for six weeks. I'm experiencing a lot of the same side effects as everyone else. No nausea, but definitely the cramping, bloating, sore stomach, and constipation. Had to do two fleet routines already. Weight loss has been fantastic, but I'm beginning to worry now. Twenty pounds so far and still dropping. .25 mg dose. Sugar numbers have been great. Don't think it's worth all the side effects. Going back to Farxiga. Much more predictable."

• Wah...
• Taken for 1 to 6 months
• August 10, 2019

For Type 2 Diabetes "I started taking Ozempic (semaglutide) five weeks ago to control my A1C, blood sugar, and weight loss, but I don't see any change. I got gas, bloated, stomach upset, and constipated. Out of the five weeks, three of them I got a UTI, and I am miserable. Going to see my regular doctor today because my endocrinologist who prescribed this medication is off during the weekend."

• Nan...
• Taken for 6 months to 1 year
• February 18, 2021

For Type 2 Diabetes "After reading the reviews, a lot of my problems using Ozempic have been answered. I was wondering why I had the side effects that I did, such as vomiting, diarrhea, bloating, stomach gurgling, and belching or egg taste, etc., but a lot has been answered here. My only comment about this is that I am to use .50 every week, and my pen only holds 3 weeks' worth. I have called 2X after I mentioned it to my nurse practitioner, and the only thing I get is offered a voucher for a free pen. My question is, am I the only one that doesn't get the full 4 weeks' worth of the pen if using .50? I tried to ask that to customer service this morning, and she could not answer my question but only offer yet another voucher. Please tell me if I am the only one that this happens to or not. Overall, I am extremely happy with the product."

• hal...
• Taken for less than 1 month
• June 4, 2023

For Type 2 Diabetes "The major side effects are all I got with this med, which includes upset stomach, heartburn, burping, gas, bloating, nausea, vomiting, stomach pain, loss of appetite, stomach flu symptoms, headache, dizziness, and tiredness."

• fem...
• Taken for 6 months to 1 year
• September 23, 2023

For Type 2 Diabetes "Serious stomach issues, cramping, bloating, severe constipation, nausea, no appetite, rashes, pain in the upper and lower bowel, gas. Loss of too much weight, no taste for food. Have had previous trouble with colitis and diverticulitis but still prescribed this medication. Only have 1 kidney and now afraid it may be damaged. I have been on this drug for approximately 7-9 months. Now worried, but the doctor is not concerned enough to take me off this medication."

• LLK...
• Taken for less than 1 month
• April 10, 2021

For Type 2 Diabetes "I was put on Ozempic for type 2 diabetes. The first week, I suffered bloating, sour stomach, and diarrhea. I was told it was temporary and it would get better. The next week, everything was worse and projectile vomiting was added. I took the third dose and nothing was better. I told the nurse about my experience and was told to stop the medication. I just don't know how long it will be before all the residual will get out of my body. I know this med works great for a lot of people, but not for me."

• Sar...
• Taken for 1 to 6 months
• October 30, 2022

For Cardiovascular Risk Reduction "I have been on Ozempic for 4 months now for weight loss. Initially, I had some GI side effects (bloating and stomach upset), but after a few weeks that mostly went away. My appetite is low (which is the intended effect), and I have not been enjoying meat as much, but otherwise, I am happy with the way this is going. As of now, I lost 14 pounds. Would recommend this medicine to everyone trying to lose weight, except for the fact that it is quite expensive. I had trouble finding a prescriber because Wegovy, which is FDA approved, is backordered everywhere. And Ozempic is the same medication, but not technically approved."

• Pau...
• Taken for less than 1 month
• January 25, 2023

For Type 2 Diabetes "I took one injection of 1 mg as prescribed. I have been sick for a week with severe constipation, nausea, dizziness, stomach upset/pain, acidity, gas bloating. I could not eat or sleep comfortably at night. This is very strong and mainly suppresses the appetite. I never had this much sickness from a drug."

• Ano...
• Taken for less than 1 month
• June 26, 2025

For Type 2 Diabetes "Week 4 and having some stomach issues, bloating, gas."