Skip to main content

Ozempic and Fatigue: What Users Say (Page 2)

Reviews for Ozempic

Commonly mentioned side effects
  • Per...
  • Taken for 1 to 6 months
  • April 13, 2022

For Type 2 Diabetes "Ozempic has changed my life and put my diabetes in remission. I am 5 foot 5 and weighed 155 pounds. I now weigh 120. The downside is that it took me two months to adjust to the drug. I went from .25 to eventually a weekly dose of .50. Those two months were horrible, but I persevered. The symptoms were extreme nausea and fatigue. The other challenge is that I have to be sure to keep up my caloric intake so that I don’t continue to lose weight. I am at my ideal weight, but I want to maintain it rather than lose any more."

10 / 10
Was this helpful?YesNo
8 Report
  • Sid...
  • Taken for 1 to 2 years
  • August 18, 2022

For Type 2 Diabetes "My side effects were bad burping and gas, extreme abdominal pain radiating into my back, headaches, extreme fatigue, and more. Three trips to the ER, one MRI, one ultrasound, and three CT scans, and the consistent diagnosis was 'everything looks perfect.' Very disappointed that an ER, GP, endocrinologist, and GI specialist all did not seem to recognize these drug side effects. I see the endocrinologist today and will discuss, looking for better options. I have had a horrible nine months. Very disappointed in both our healthcare chemists and industry in general."

2 / 10
Was this helpful?YesNo
8 Report
  • Blu...
  • Taken for less than 1 month
  • January 2, 2019

For Type 2 Diabetes "I am on my 3rd week of Ozempic. So far, the only noticeable side effects have been fatigue, slight headache after injection, and it has stirred up my GERD a bit. It seems to be working with me. I am hoping all stays as it is now. Probably lucky on the side effects. I delayed taking for 2 weeks to wrestle with the possible side effects."

8 / 10
Was this helpful?YesNo
12 Report

Frequently asked questions

  • Goa...
  • Taken for 1 to 6 months
  • July 20, 2021

For Type 2 Diabetes "I have taken 7 doses of Ozempic. The first week wasn't too bad. A little nausea and fatigue. I did feel like my food stuck in my throat, and every time I burped, there it was. As I continued to take it each week, the side effects got worse. I was just diagnosed with diabetes in May, and since then, I've been able to come off of my insulin on my own, before Ozempic. I still take Metformin twice a day. This past week, the seventh dose made me so sick! If I wasn't nauseous every day, I was running to the bathroom at all hours of the day and night. I had horrible heartburn, gas, burping, jitters, and dizziness the whole time and thought I could continue, but after this past week, my doctor said to come off of it. It will take a while to get out of my system, I know, but I hope it does so quickly. I need my life back!!"

1 / 10
Was this helpful?YesNo
8 Report
  • Iri...
  • Taken for 1 to 6 months
  • October 10, 2019

For Type 2 Diabetes "Started Ozempic a month ago. I had a bit of diarrhea with the first two injections. Now it is just the headache and fatigue feeling. I haven't noticed any changes in appetite. I had been losing weight for three months prior to starting Ozempic. I was down 42 pounds, since starting, I'm up six pounds. I haven't noticed any difference in my blood sugar numbers. Not impressed so far."

4 / 10
Was this helpful?YesNo
10 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Art...
  • Taken for less than 1 month
  • March 14, 2019

For Type 2 Diabetes "I had my first Ozempic 1mg shot on Monday for weight loss. My appetite is well under control. I am experiencing fatigue, especially after eating, requiring me to take a couple of naps a day. I hope my body adjusts to it. I am still able to function and am actually going to the gym every day and eating about 1000 calories per day. My goal is to lose about 35 pounds and then hope to be able to maintain my weight on diet and exercise alone."

8 / 10
Was this helpful?YesNo
11 Report
  • RNJ...
  • Taken for less than 1 month
  • February 16, 2025

"Everyone is different. I really wanted it to work for me, but I cannot tolerate it. At first, I thought it was magic, it took away all food cravings, and I could no longer eat large meals. I tried to stay hydrated and eat a high-protein diet, but I still felt very fatigued. I also experienced low blood sugar and would have to force myself to eat to make the shakes go away. Even my favorite foods no longer taste good, and I have felt depressed. I cannot wait for it to clear my system. Just know some can tolerate the side effects, and some cannot."

4 / 10
Was this helpful?YesNo
1 Report

More FAQ

  • Mar...
  • Taken for 1 to 6 months
  • February 4, 2025

For Type 2 Diabetes "I have been on Ozempic for 6 months. My A1C was 10, it is now 6.9. I thought it would be lower after 6 months. I have lost 45 lbs. because it killed my appetite, so some days I don’t eat at all. Side effects: diarrhea after eating, nausea, fatigue, just feeling blah."

5 / 10
Was this helpful?YesNo
1 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 4, 2024

For Type 2 Diabetes "On the plus side, Ozempic quickly began to lower my blood sugar, which metformin alone was no longer able to do, despite exercise & diet control, so that I was back into more normal numbers. I still take metformin. I had some constipation, but worked through that issue & mild nausea also appeared, but then disappeared. My overeating for stress & or boredom was much easier to manage, I thought about eating poor choices & then was able to push the thought away. The biggest challenge was fatigue, I often am feeling very sluggish & sleepy & have to push through chores like grocery shopping. I’ve lost 5 lbs in 2 months & want to lose 15 more lbs to achieve my goal, so I hope the fatigued side effect will diminish. Easy to learn how to administer from the instructions. I’m on 0.5 dosage & believe I will increase to 1 dosage within the month."

8 / 10
Was this helpful?YesNo
2 Report
  • Ren...
  • Taken for 1 to 6 months
  • July 22, 2022

For Type 2 Diabetes "I am a 68-year-old male with Type 2 diabetes. I tried Ozempic .025 low dose, to also lose weight. Have been on it for 5 weeks and have had an upset stomach and constipation since the beginning. Only lost 6 lbs. To me, the side effects of always feeling sick and not hungry, which for me led to tiredness and fatigue, even though I take vitamins, is definitely not worth it. Blood sugar went down below 100 for the first 3 weeks but has gone back to upper normal, 140-150 since then. Not worth it to feel sick all the time. I am quitting this stuff."

2 / 10
Was this helpful?YesNo
5 Report
  • Jea...
  • Taken for less than 1 month
  • June 7, 2023

For Type 2 Diabetes "Nausea, bad acid reflux at night, nightmares, headache every morning, constipation, chills, fatigue. Just started a week ago. Blood sugar levels in the 80s and 90s. Have lost no weight. Zero appetite. Blurry vision."

7 / 10
Was this helpful?YesNo
3 Report
  • ric...
  • Taken for 1 to 6 months
  • March 25, 2023

For Type 2 Diabetes "I have had terrible side effects from this medication. My legs have swollen to the point of impaired walking, trouble raising either leg to use the shower/tub, and am unable to stand for very long. Shortness of breath, difficulty retaining breath, higher blood pressure, and general fatigue. As for benefits, I really have not noticed any as yet, been too busy coping with the new problems."

3 / 10
Was this helpful?YesNo
3 Report
  • Cat...
  • Taken for 6 months to 1 year
  • March 8, 2023

For Type 2 Diabetes "I've been on Ozempic 0.25 mg since last March. Had a lot of stomach problems for the first 3 months and stopped for a month to calm my stomach. Lost 16 pounds in the beginning, but that has come to a standstill. I have noticed, besides stomach issues, mood swings, mild depression I didn't have prior, fatigue, and still ongoing stomach issues. I will probably stop. While it notes there are cardiology benefits, for me, it's just not worth the side effects. My advice is to make sure you keep in touch with your doctor and tell them how you are feeling."

4 / 10
Was this helpful?YesNo
3 Report
  • Pea...
  • Taken for 1 to 6 months
  • February 21, 2023

"I underwent lap band surgery several years ago and am currently taking Ozempic. If given the option, I recommend choosing Ozempic over lap band surgery due to their similar side effects. However, if it is possible to manage diabetes and weight with an alternative medication, I suggest doing so. It's important to administer the injection in the thigh, as other injection sites tend to cause worse side effects. The side effects of Ozempic are persistent and severe, and unfortunately, they are unpredictable. One week you may experience minimal side effects, while the next week, at the same dosage, the side effects may be so severe that you will need to miss work. Ozempic causes extreme fatigue, unlike any other fatigue I have experienced. My eyes struggle to stay open. Additionally, I have suffered from intense constipation for two weeks with minimal relief from laxatives, followed by a few days of uncontrollable diarrhea and acid reflux. I no longer enjoy food; it no longer tastes good, and fruit or tea is no longer refreshing or soothing. I believe there must be a balance between enjoying food and weight loss."

6 / 10
Was this helpful?YesNo
3 Report
  • Jen...
  • Taken for less than 1 month
  • August 19, 2021

For Type 2 Diabetes "I was prescribed Ozempic for Type 2 diabetes to help lower my blood sugar and to help with weight loss. The first week wasn't so bad, just a little fatigued and some upset stomach problems. The second week it kicked in overtime and hit me like a brick wall. I had no energy at all. Stayed in bed because it's all I could do. My stomach was so upset and nausea, vomiting, and diarrhea were so bad, it ran like water. I became more dehydrated with less energy. I have 4 autoimmune diseases and this was the sickest I have ever felt in my life. I almost went to the ER and if not for Covid, I would have. It felt like someone had been feeding me rat poison. It's the worst feeling ever. I truly don't know how this drug was approved by the FDA. I plan to take myself off it. Weight loss and blood sugar need to be done in a healthier manner. Lose weight fast and easy has consequences."

1 / 10
Was this helpful?YesNo
4 Report
  • Suz...
  • Taken for less than 1 month
  • July 22, 2021

For Type 2 Diabetes "I’ve taken two doses of Ozempic .25 mg and been on the drug for 1 1/2 weeks. I won’t be able to continue. This is a very harsh drug, and the side effects are terrible, in my opinion. I did not suffer from nausea and vomiting but couldn’t eat, food tasted horrible, my body stopped absorbing fat (evidenced in my stools), had lightheadedness, and the worst fatigue imaginable. In 1 1/2 weeks, I’ve dropped 10 pounds and feel undernourished and dehydrated. Be careful!"

2 / 10
Was this helpful?YesNo
4 Report
  • Kat...
  • Taken for 2 to 5 years
  • October 10, 2024

For Type 2 Diabetes "I have been on Ozempic for Type 2 diabetes. Was overweight as well, I am 4'11 and had ballooned to over 170 pounds. I was taking medicine for blood pressure, anxiety, depression, you know, all the things. I started in March 2022. My A1c was 7.9. Today I am down to 105 (hold up, that is normal for my height). No more high pressure. Beginning, I wasn't sure I would get past the nausea, but I fought through it, and yes, it does go away. I have been on stool softeners for a while, so I have never had any issues going to the restroom. My A1c is 5.4 now. I don't feel good, though. I can't put my finger on it, but I am severely exhausted and fatigued. I will not trash this medicine because I think it works as it should and has been amazing for diabetics. I just wish I didn't feel like poo all the time. The side effects do subside over time. My doctor and I have found the perfect dosing and schedule for me to keep my blood sugar under control."

10 / 10
Was this helpful?YesNo
1 Report
  • Apr...
  • Taken for 1 to 6 months
  • August 25, 2021

For Type 2 Diabetes "I have been on Ozempic for 20 weeks now, and I still experience bloating, flatulence, nausea, and fatigue. My A1C went back to normal, but I feel sick all the time. My most horrible side effect is the rotten egg smell of my burps. I am also taking Toujeo and Janumet."

5 / 10
Was this helpful?YesNo
3 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 30, 2024

For Type 2 Diabetes "After 4-6 weeks, I still suffer various levels of intensities of nausea, but short-lived diarrhea, plenty of burping, and fatigue that is often overwhelming. Some days, no problems. I manage the symptoms by enduring until they ease up, or I may choose to seek fast relief using what's available. Its benefits are now close to 'tight control' and significant weight loss (overcoming the stagnant plateau of a period of weight loss)."

9 / 10
Was this helpful?YesNo
1 Report
  • Suz...
  • Taken for 1 to 6 months
  • June 20, 2022

For Cardiovascular Risk Reduction "I started Ozempic in January 2022. Began with the standard .25 for 4 weeks, then .50 for an additional 4. When I injected the 1 mg, I was sick constantly. Vomiting, fatigue, and horrible heartburn. I had to stop for several weeks as I was completely worn out. I started again with the .25 and am now on the .50, but I'm noticing I am much more hungry than I was the first time around. I was wondering if any of you have injected .75 and if you found it to be helpful? I am afraid to try the 1 mg again as sick as it made me."

7 / 10
Was this helpful?YesNo
2 Report
  • Mem...
  • Taken for less than 1 month
  • September 3, 2021

For Type 2 Diabetes "I have Type 2 diabetes that I’ve kept under control by taking Metformin, Jardiance, and insulin. I saw a new endocrinologist 2 weeks ago who suggested I try Ozempic, with the hope of eliminating the insulin. She prescribed taking .25 mg initially for 4 weeks and then bumping up to .50, also reducing my insulin to 15 units and hopefully eliminating it later. She did say it could cause some stomach issues, but mainly said it could make you not want to eat much. I think in hindsight she downplayed the side effects. I took my first dose a week ago. The first 3 days were fine. The 4th day I started having foul-tasting belches and then got such severe stomach/gas cramping I almost went to the ER. I have a high pain tolerance, so for me to be in that much pain says a lot. I was able to finally get relief by drinking baking soda water, but then had extreme diarrhea, nausea, body aches, and fatigue. I missed 2 days of work. I called the doctor, and she said my symptoms were severe and to stop taking it. Horrible experience!"

1 / 10
Was this helpful?YesNo
2 Report
  • Bra...
  • Taken for 1 to 6 months
  • July 31, 2021

For Type 2 Diabetes "I have been taking Ozempic for about 4 months now. Haven’t had really bad side effects, but sometimes I feel just exhausted and somewhat out of breath. I also have muscle aches and fatigue. Not lost a lot of weight, maybe 2 lbs. I keep hoping. Does anyone else have similar side effects? Good luck and all the best results for everyone."

5 / 10
Was this helpful?YesNo
2 Report
  • S-L...
  • Taken for 6 months to 1 year
  • February 2, 2023

For Type 2 Diabetes "Major nausea ebbs and flows. Extremely bad fatigue off and on. More along the lines of exhaustion. No weight loss. I’m on a pretty high dose, 1.5, and am only about 15 lbs overweight. Diabetes type 2 most of my life, so this is a great drug. Hopefully, the next generation of these drugs will have fewer side effects for some of us. The nausea and fatigue are pretty overwhelming some days. A1c has improved, so I will stay on until something better comes along."

6 / 10
Was this helpful?YesNo
1 Report
  • Rob...
  • Taken for 1 to 6 months
  • March 1, 2025

"I have been taking Ozempic for five months, and I have lost 35 pounds. That’s the good part. I continue to have very bad fatigue, and when I upped my dose, I find myself nauseous and vomiting. I’m gonna continue taking it for a little while longer to reach my goal. So far, it has been worth it for me."

8 / 10
Was this helpful?YesNo
0 Report
  • jud...
  • Taken for 1 to 6 months
  • March 15, 2025

For Cardiovascular Risk Reduction "2-3 days per week I suffer from poor sleep and fatigue accordingly. Trying to get to sleep is bad, with body noises making it impossible. Also, constant burping with gas buildup, farting at night is awful, watery eyes. The other 4 days is fine. The days are not in a row and often vary each week. My rating of the medicine would vary on different days, bad days, bad rating."

6 / 10
Was this helpful?YesNo
0 Report

See also:

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.