Skyrizi for Crohn's Disease User Reviews
Reviews for Skyrizi
- mgc...
- Taken for 1 to 2 years
- September 15, 2023
"This drug has been an absolute miracle and should be the first-line treatment for many Crohn's patients to speak to their doctor about. After 13+ years of different medications, this is the only one that has given both symptom relief and also a 90% improvement in inflammation/lab markers. Honestly, it delivers what the commercials promise. However, it is very expensive and critical to have good insurance. The on-body injector is the easiest and most pain-free injection method I have had. It took about 6 months to really see marked results in labs. In my journey, I've tried Humira (became ineffective), all the pill/foam/suppository options (zero improvement), Entyvio (worked some but the infusion center schedule was difficult with my work travel), lastly Stelara and Cimzia, which caused neurological issues including a tonic-clonic meltdown with Cimzia specifically. I cannot think of any side effects to date other than no longer looking for a bathroom constantly. Nothing is truly everything."
- Gut...
- Taken for 1 to 6 months
- March 19, 2025
"100% not saying this will happen to you, but I do want to report what happened with my wife. She has taken many biologics over the years from Remicade to Entyvio and beyond, and this is the first time this has ever happened to us. We began the treatment in November 2024, and as of today, March 2025, all of my wife's hair has fallen out. Now she is not like the poor cancer chemo patients who go completely bald, but she has just stubble now, and we have had to purchase a wig for her. It seemed to be working basically just... okay, but the hair loss is just too much for us, and we are jumping ship at this point. She had the best response to this, 'If it is doing this to me outside, I can't imagine what it is doing to me inside!' She is spot on. I hope you have better results, and I hope that the drug company does not force this to be removed, there are also several reports of this on Reddit as well. Good luck and keep fighting the good fight."
Frequently asked questions
- Who is the actress in the Skyrizi commercial?
- What are Monoclonal Antibodies and how do they work?
- What are IL-23 Inhibitors and how do they work?
- What's the dosing schedule for Skyrizi?
- Bil...
- Taken for 1 to 6 months
- December 29, 2023
"I have had the two infusion doses. No side effects except my anemia is worse. Which may not be related. It is almost like I don't have Crohn's anymore. I was doing well with Inflectra but developed antibodies to it."
- Gle...
- Taken for 1 to 6 months
- April 8, 2024
"Previously on Entiviyo until efficacy declined and symptoms came back. Skyrizi chosen due to past history with CNS lymphoma. Symptoms disappeared after initial dosing of Skyrizi. Just had my second 8-week interval self-dosing and still no Crohn’s symptoms. I have had a bout of pneumonia (not new for me) while on Skyrizi. My immunoglobulin G was just tested and is slightly below acceptable range. Self-dosing is easy to do and have had no problems."
- Bil...
- Taken for 1 to 6 months
- December 29, 2023
"I have had the two infusion doses. No side effects except my anemia is worse. Which may not be related. It is almost like I don't have Crohn's anymore. I was doing well with Inflectra but developed antibodies to it."
- Chr...
- Taken for 6 months to 1 year
- May 23, 2025
"Although my intestines look improved and inflammation markers are looking much better, I will be stopping very soon. My pain in my stomach and intestines, along with bloating, are much worse. Quality of life counts."
More FAQ
- Does Skyrizi cause cancer?
- Can you drink alcohol while taking Skyrizi?
- Is Omvoh the same as Skyrizi?
- Who makes Skyrizi and where is it made?
- Ano...
- Taken for 1 to 2 years
- July 12, 2025
"Truly has changed my life for the better. No side effects, and my Crohn's is pretty much under control with minimal flare-ups. My ONLY complaint is the dosing...8 weeks was not good for me as it didn't last in my system that long. It seems if the levels begin to dip a little, I am flaring. My doctor was able to get me approved (after 3 appeals with insurance) for every 6-week use. Since beginning a 6-week dosing interval, I have completely eliminated the need for budesonide. I hope this drug continues working for years to come. The only thing I wish that I knew about Skyrizi is there is not a test to check for antibodies like other biologics have. If I would have known this when picking my drug, that may have influenced my decision."
- Fli...
- Taken for 1 to 6 months
- April 9, 2023
"Skyrizi caused serious liver damage to me! After only being on this medication for the initial 3 infusions, it has caused severe hepatic steatosis."
- Tom...
- Taken for 6 months to 1 year
- November 25, 2024
"Very good, no issues. It has completely stopped the issues I had with Crohn's, with no side effects."
See also:
Learn more about Crohn's Disease
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"I'm in a clinical trial taking Skyrizi to treat my Crohn's disease symptoms. I've been injecting the medicine every 8 weeks for at least the last two years and I'm happy to report I've been in remission and symptom-free. The downside: it has wreaked havoc on my immune system and I get sick with everything to the extreme now. My body cannot fight off anything I'm exposed to. I've also gained a major amount of weight: 30 pounds in one year! My doctor says it's normal because I'm not in malabsorption anymore, but it's as if my metabolism has slowed versus absorbing. I don't eat any more than usual, yet keep gaining weight."